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Pay vs Performance Disclosure

12 Months Ended

Dec. 31, 2022

USD ($)

Dec. 31, 2021

USD ($)

Dec. 31, 2020

USD ($)

Pay vs Performance Disclosure [Table]

Pay vs Performance [Table Text Block]

Pay Versus Performance

The disclosure provided in this section is required by the SEC and does not necessarily align with how the Company has historically viewed the relationship between its performance and the compensation of its Named Executive Officers. We believe our discussion in the “Compensation Discussion and Analysis” provides a more fulsome view of how we view our executive compensation structure and how that aligns with the Company’s performance and objectives.

In accordance with Item 402(v) of Regulation S-K, the following table shows the total compensation for our Named Executive Officers for fiscal 2022, 2021, and 2020 as set forth in the Summary Compensation Table (the “SCT”), the “compensation actually paid,” as computed in accordance with Items 402(v) of Regulation S-K (the “CAP”), to our CEO, and, on an average basis, the compensation actually paid to our other Named Executive Officers (the “other NEOs”), our total shareholder return (“TSR”), the TSR of the Nasdaq Biotechnology Index, which constitutes the “Peer Group”, our net income, and our revenue, which is our company selected financial measure, all measures over the same time period.

For purposes of the chart below, Dr. Hsiao, Messrs. Rubin and Logal, and Jon Cohen are the other NEOs for fiscal 2022, 2021, and 2020. Dr. Zerhouni’s compensation is also taken into consideration in the compensation of our other NEOs with respect to a portion of fiscal 2022.

YEAR⁽¹⁾	SCT TOTAL PAY FOR CEO(2)		CAP to CEO⁽³⁾			AVG SCT TOTAL PAY FOR OTHER NEOS		AVG CAP TO OTHER NEOS			Value of Initial $100 Investment Based on:⁽⁴⁾				Net Income⁽⁵⁾			Revenue⁽⁶⁾
											Company TSR		Peer Group TSR
2022		972,200		(1,247,785	)		803,001		(1,324,485	)		85.03		113.65		(328,405	)		1,004,196
2021		2,103,600		2,396,962			2,298,100		2,789,211			327.21		126.45		(30,143	)		1,774,718
2020		1,538,200		3,327,922			1,945,950		3,742,579			268.71		126.42		(30,586	)		1,435,413

⁽¹⁾ For fiscal 2022, 2021, and 2020, Dr. Phillip Frost was the CEO.

⁽²⁾ These amounts reflect (i) the total compensation reported in the SCT for the applicable year in the case of our CEO; and (ii) the average of the total compensation reported in the SCT for the applicable year for our other NEOs. See the footnotes to the SCT for further detail regarding the amounts in this column.

⁽³⁾ Amounts reported in these columns represent CAP, which was computed by making certain adjustments to the amounts reported in the SCT for the applicable year. A reconciliation of the adjustments for our CEO and for the average of the other NEOs is set forth in the following tables, which describe the adjustments.

⁽⁴⁾ Reflects the cumulative TSR for the Company and the NASDAQ Biotechnology Index, which is the same industry index included in Part II, Item 5, “Market for Registrant’s Common Equity, Related Stockholder Matters, and Issuer Purchases of Equity Securities,” furnished in the Company’s Annual Report on Form 10-K filed with the SEC on February 27, 2023, assuming, in each case, an initial investment of $100 on December 31, 2019.

⁽⁵⁾ Reflects “Net Income” in the Company’s consolidated statement of operations included in the Company’s Annual Report on Form 10-K for each of the years ended December 31, 2022, 2021, and 2020.

⁽⁶⁾ SEC rules require us to designate a “company-selected measure” that in our assessment represents the most important financial performance measure (that is not otherwise required to be disclosed in the table immediately above) used by the Company to link the CAP of our Named Executive Officers, for the most recently completed fiscal year, to our performance. We selected revenue as this measure for fiscal 2022, as reflected in the table above. This performance measure may not have been the most important financial performance measure for fiscal 2021 and 2020, and we may determine a different financial performance measure to be the most important financial performance measure in future years.

PEO Total Compensation Amount

$ 972,200

$ 2,103,600

$ 1,538,200

PEO Actually Paid Compensation Amount

$ (1,247,785)

2,396,962

3,327,922

Adjustment To PEO Compensation, Footnote [Text Block]

YEAR	SCT TOTAL PAY FOR CEO		MINUS EQUITY AWARD GRANT DATE FV REPORTED IN SCT FOR COVERED YEAR		PLUS YE FV OF EQUITY AWARDS GRANTED DURING THE COVERED YEAR THAT REMAIN OUTSTANDING AND UNVESTED		PLUS YOY CHANGE IN FV OF OUTSTANDING AND UNVESTED EQUITY AWARDS GRANTED IN PRIOR YEARS			PLUS YOY CHANGE IN FV AS OF THE VESTING DATE OF EQUITY AWARDS GRANTED IN PRIOR YEARS THAT VESTED DURING COVERED YEAR			CEO CAP
2022		972,200		—		—		(1,522,307	)		(697,678	)		(1,247,785	)
2021		2,103,600		1,132,000		1,116,026		390,724			(81,388	)		2,396,962
2020		1,538,200		567,000		1,212,445		968,750			175,527			3,327,922

Non-PEO NEO Average Total Compensation Amount

$ 803,001

2,298,100

1,945,950

Non-PEO NEO Average Compensation Actually Paid Amount

$ (1,324,485)

2,789,211

3,742,579

Adjustment to Non-PEO NEO Compensation Footnote [Text Block]

YEAR	SCT AVERAGE PAY FOR OTHER NEOs		MINUS EQUITY AWARD GRANT DATE FV REPORTED IN SCT FOR COVERED YEAR		PLUS YE FV OF EQUITY AWARDS GRANTED DURING THE COVERED YEAR THAT REMAIN OUTSTANDING AND UNVESTED		PLUS YOY CHANGE IN FV OF OUTSTANDING AND UNVESTED EQUITY AWARDS GRANTED IN PRIOR YEARS			PLUS YOY CHANGE IN FV AS OF THE VESTING DATE OF EQUITY AWARDS GRANTED IN PRIOR YEARS THAT VESTED DURING COVERED YEAR			AVG OTHER NEO CAP
2022		803,001		8,801		8,091		(886,469	)		(1,240,307	)		(1,324,485	)
2021		2,298,100		1,202,750		1,116,026		541,634			36,202			2,789,211
2020		1,945,950		801,000		1,784,988		685,393			127,248			3,742,579

The fair value of options was determined by using the Black-Scholes option pricing method.

Compensation Actually Paid vs. Total Shareholder Return [Text Block]

Relationship Between “Compensation Actually Paid” and Performance Measures. The charts below compare the CAP to our CEO and the average CAP to our other NEOs with (i) our TSR, (ii) our net income, (iii) revenue, which is our company selected measure, for fiscal 2022, 2021 and 2020. In addition, the charts below compare our TSR with our Peer Group TSR. We believe the CAP in each of the years reported above aligns with the performance metrics presented. In example, the CAP to the CEO and average CAP to our other NEOs in fiscal 2022 was negative, as was our TSR, and we reported a net loss and decline in revenue during that period.

Non-Financial Performance Measures. The Company also considered the success, failure or progress made with respect to its R&D pipeline in setting pay-for performance compensation for fiscal 2022.

Compensation Actually Paid vs. Net Income [Text Block]

Compensation Actually Paid vs. Company Selected Measure [Text Block]

Tabular List [Table Text Block]

Financial Performance Measures. The most important financial performance measures used by the Company in setting pay-for-performance compensation for fiscal 2022 are set forth below, in no particular order.

-Adjusted Operating Income

-Revenue

-Relative Total Shareholder Return

Total Shareholder Return Amount

$ 85.03

327.21

268.71

Peer Group Total Shareholder Return Amount

113.65

126.45

126.42

Net Income (Loss)