X0508 4 2023-11-10 0 0000944809 OPKO HEALTH, INC. OPK 0001188834 HSIAO JANE PH D OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 1 1 0 0 Vice Chairman & CTO 0 Common Stock 2023-11-10 4 P 0 34058 1.26 A 27633928 D Common Stock 2023-11-10 4 P 0 65942 1.27 A 27699870 D Common Stock 5127404 I See Footnote The securities are owned directly by Hsu Gamma Investment, L.P. Dr. Hsiao is the general partner of Hsu Gamma Investment, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. Steven D. Rubin, Attorney-in-Fact 2023-11-13