X0306 4 2018-11-08 0 0000944809 Opko Health, Inc. OPK 0001188834 HSIAO JANE PH D OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 1 1 0 0 Vice Chairman & CTO Common Stock 2018-11-08 4 A 0 573066 3.49 A 25346199 D Common Stock 4617404 I See Footnote Common Stock 1000000 I See Footnote Common Stock 1000000 I See Footnote Common Stock 20091062 I See Footnote The securities are owned directly by Hsu Gamma Investment, L.P. Dr. Hsiao is the general partner of Hsu Gamma Investment, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The securities are held by The Chin Hsiao Family Trust A, of which Jane H. Hsiao, Ph.D. is the trustee. The securities are held by The Chin Hsiao Family Trust B, of which Jane H. Hsiao, Ph.D. is the trustee. These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. Jane Hsiao, Ph.D. 2018-11-13