X0306 4 2018-09-07 0 0000944809 Opko Health, Inc. OPK 0001735476 Fishel Robert Scott 4400 BISCAYNE BLVD. MIAMI FL 33137 1 0 0 0 Common Stock 2018-09-07 4 P 0 10000 4.63 A 4070728 I See Footnote These securities are held by ALSAR Ltd. Partnership, of which Dr. Fishel is the President and CEO. The general partner of ALSAR Ltd. Partnership is SARAL Corporation. Dr. Fishel is the sole shareholder and the sole and exclusive beneficiary of SARAL Corporation. Adam Logal, Attorney-In-Fact 2018-09-10