X0306 4 2018-03-07 0 0000944809 Opko Health, Inc. OPK 0001381874 Rubin Steven D OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 1 1 0 0 Executive VP-Administration Common Stock 2018-03-07 4 P 0 6000 3.25 A 5691915 D Common Stock 20091062 I See Footnote These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. Steven D. Rubin 2018-03-08