X0306 4 2017-04-12 0 0000944809 Opko Health, Inc. OPK 0001381874 Rubin Steven D OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 1 1 0 0 Executive VP-Administration Common Stock 2017-04-12 4 M 0 265000 2.36 A 5840251 D Common Stock 2017-04-12 4 F 0 158336 7.66 D 5681915 D Common Stock 20091062 I See Footnote Stock Option (Right to Buy) 2.36 2017-04-12 4 M 0 265000 0.00 D 2017-04-13 Common Stock 265000 0 D Represents the number of shares withheld by the Company at the direction of the reporting person for payment of the exercise price and tax liability in connection with the exercise of the stock option. No shares of Common stock were sold by the reporting person in connection with this transaction. The reporting person has retained the net number of shares issued upon the exercise of the option, less the amount retained to pay the associated tax liability (106,664 of shares). Closing market price of the Company's common stock on the transaction date. These securities are owned directly by The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. The options were granted on April 14, 2010 and vest in four equal installments beginning on April 14, 2011. Steven D. Rubin 2017-04-13