X0306 4 2017-02-22 0 0000944809 Opko Health, Inc. OPK 0001236687 PAGANELLI JOHN A 1250 PITTSFORD-VICTOR ROAD BUILDING 200 - SUITE 280 PITTSFORD NY 14534 1 0 0 0 Common Stock 2017-02-22 4 M 0 20000 2.05 A 344208 D Common Stock 2017-02-22 4 F 0 4853 8.45 D 339355 D Common Stock 4175 I See Footnote Stock Option (Right to Buy) 2.05 2017-02-22 4 M 0 20000 0.00 D 2011-05-27 2017-05-26 Common Stock 20000 0 D Represents number of shares withheld by the Company at the direction of the reporting person for the payment of exercise price. No shares of Common Stock were sold by the reporting person in connection with this transaction. The reporting person has retained the net number of shares issued upon the exercise of the option (15,147 shares). Closing market price of the Company's common stock on the transaction date. These securities are owned by Mr. Paganelli's spouse. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purposes. Adam Logal, Attorney-In-Fact 2017-02-28