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Note 14 - Strategic Alliances (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 25 Months Ended 39 Months Ended
Mar. 16, 2025
Mar. 08, 2023
Sep. 14, 2021
Jun. 18, 2021
May 05, 2020
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Mar. 31, 2023
Sep. 30, 2025
Sep. 30, 2024
Mar. 31, 2025
Mar. 31, 2025
Jan. 07, 2025
Dec. 31, 2024
Sep. 29, 2024
Oct. 01, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax             $ 151,669 $ 173,632   $ 458,429 $ 529,504            
Corporate Joint Venture [Member] | LeaderMed Joint Venture [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax     $ 1,000                            
Subsidiary, Ownership Percentage, Parent     47.00%                            
LeaderMed [Member] | Corporate Joint Venture [Member] | LeaderMed Joint Venture [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Payments to Acquire Interest in Joint Venture     $ 11,000                            
Subsidiary, Ownership Percentage, Noncontrolling Owner     53.00%                            
Collaboration and License Agreement With Entera [Member] | Entera Ordinary Shares [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Investment Owned, Shares Purchased (in shares) 3,685,226                                
Shares Purchased, Price Per Share (in dollars per share) $ 2.17                                
Payments to Acquire Investments $ 8,000                                
Collaboration and License Agreement With Entera [Member] | Opko [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership, Percentage 60.00%                                
Collaboration and License Agreement With Entera [Member] | Opko [Member] | Entera Discontinuing Funding [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership, Percentage 85.00%                                
Collaboration and License Agreement With Entera [Member] | Entera [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership, Percentage 40.00%                                
Collaboration and License Agreement With Entera [Member] | Entera [Member] | Entera Discontinuing Funding [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Ownership, Percentage 15.00%                                
BARDA Agreement [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Collaborative Arrangement, Supplement for Advance of Development           $ 26,900   26,900     26,900            
Revenue from Contract with Customer, Excluding Assessed Tax           24,100 8,200 5,500   21,600 12,800            
Collaborative Arrangement, Value           110,000   110,000     110,000         $ 59,000  
Collaborative Arrangement, Value, Including Milestones           $ 205,000   $ 205,000     $ 205,000         $ 168,600  
Aggregate Transaction Price Allocated to Remaining Performance Obligations, Excluding Unexercised Contract Options, Amount                   63,400              
Merck Agreement [Member] | Merck Sharp & Dohme LLC [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax   $ 50,000                              
Collaborative Arrangement, Development Milestone Payment   $ 860,000                       $ 12,500      
Collaborative Arrangement, Development Costs                       $ 26,800          
Development and License Agreement [Member] | NICOYA Macau Limited [Member] | EirGen [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax       $ 5,000         $ 2,500                
Collaborative Arrangement, Development Milestone Payment       115,000                          
Collaborative Agreement, Delayed Payment       $ 5,000                          
Collaborative Agreement, Delayed Payment Received, Cumulative                 $ 2,500                
Collaborative Arrangement, Period Following First Commercial Sale (Year)       10 years                          
Development and License Agreement [Member] | Vifor Fresenius Medical Care Renal Pharma Ltd. [Member] | EirGen [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Collaborative Arrangement, Maximum Regulatory Milestone Payments         $ 15,000                        
Collaborative Arrangement, Sales Milestone Payment         200,000                        
Collaborative Agreement, Option, Sales Milestone Payments         555,000                        
Development and License Agreement [Member] | Vifor Fresenius Medical Care Renal Pharma Ltd. [Member] | EirGen [Member] | First Marketing Approval of Rayaldee in Europe [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax         3,000                        
Development and License Agreement [Member] | Vifor Fresenius Medical Care Renal Pharma Ltd. [Member] | EirGen [Member] | Germany Price Approval by Local Sick Fund Association [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax         $ 7,000                        
Pfizer Agreement [Member] | Pfizer Inc. [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Revenue from Contract with Customer, Excluding Assessed Tax                         $ 175,000        
Collaborative Arrangement, Maximum Regulatory Milestone Payments                                 $ 275,000
Revenue, Remaining Performance Obligation, Amount                                 295,000
Contract with Customer, Liability             $ 0     $ 0         $ 0    
Pfizer Agreement [Member] | Pfizer Inc. [Member] | Minimum [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Collaborative Agreements, Each Milestone Payment                                 20,000
Pfizer Agreement [Member] | Pfizer Inc. [Member] | Maximum [Member]                                  
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                                  
Collaborative Agreements, Each Milestone Payment                                 $ 90,000