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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 IJt8IR2p4nghOp4v3dC/34aVV9nrowiu+pKfoXQ68Llmm5qsNSLULFch+y2PxWYd
 l1Vh9f3h1ikUt9ifhphm9A==

<SEC-DOCUMENT>0001144204-08-025108.txt : 20080430
<SEC-HEADER>0001144204-08-025108.hdr.sgml : 20080430
<ACCEPTANCE-DATETIME>20080430143240
ACCESSION NUMBER:		0001144204-08-025108
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080428
FILED AS OF DATE:		20080430
DATE AS OF CHANGE:		20080430

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Opko Health, Inc.
		CENTRAL INDEX KEY:			0000944809
		STANDARD INDUSTRIAL CLASSIFICATION:	BLANK CHECKS [6770]
		IRS NUMBER:				752402409
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		STREET 2:		SUITE 900
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137
		BUSINESS PHONE:		305-575-6015

	MAIL ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		STREET 2:		SUITE 900
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	eXegenics Inc
		DATE OF NAME CHANGE:	20040505

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXEGENICS INC
		DATE OF NAME CHANGE:	20011114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CYTOCLONAL PHARMACEUTICS INC /DE
		DATE OF NAME CHANGE:	19950503

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Logal Adam
		CENTRAL INDEX KEY:			0001356197

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33528
		FILM NUMBER:		08789261

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		561-989-5800

	MAIL ADDRESS:	
		STREET 1:		NABI BIOPHARMACEUTICALS
		STREET 2:		5800 PARK OF COMMERCE BLVD., N.W.
		CITY:			BOCA RATON
		STATE:			FL
		ZIP:			33487
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v112129_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-04-28</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000944809</issuerCik>
        <issuerName>Opko Health, Inc.</issuerName>
        <issuerTradingSymbol>OPK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001356197</rptOwnerCik>
            <rptOwnerName>Logal Adam</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>OPKO HEALTH, INC</rptOwnerStreet1>
            <rptOwnerStreet2>4400 BISCAYNE BOULEVARD, SUITE 1180</rptOwnerStreet2>
            <rptOwnerCity>MIAMI</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33137</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Exec.Dir .of Fin., CAO,Treas.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.65</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-04-28</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>35000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-04-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>35000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>35000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This option will vest in four equal annual installments beginning April 28, 2009.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Adam Logal</signatureName>
        <signatureDate>2008-04-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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