-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 VUqpM0OarcrJ3tuRmkbzHA/K8F+juqTZxTMz/5hWA12Vzcl/yvQinq4BG2s/2Vz2
 siCunLi6IwWexuIf3XHfog==

<SEC-DOCUMENT>0001144204-06-014722.txt : 20060411
<SEC-HEADER>0001144204-06-014722.hdr.sgml : 20060411
<ACCEPTANCE-DATETIME>20060411125356
ACCESSION NUMBER:		0001144204-06-014722
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060403
FILED AS OF DATE:		20060411
DATE AS OF CHANGE:		20060411

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			eXegenics Inc
		CENTRAL INDEX KEY:			0000944809
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				752402409
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1250 PITTSFORD-VICTOR ROAD
		STREET 2:		BUILDING 200, SUITE 280
		CITY:			PITTSFORD
		STATE:			NY
		ZIP:			14534
		BUSINESS PHONE:		585-218-4368

	MAIL ADDRESS:	
		STREET 1:		1250 PITTSFORD-VICTOR ROAD
		STREET 2:		BUILDING 200, SUITE 280
		CITY:			PITTSFORD
		STATE:			NY
		ZIP:			14534

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXEGENICS INC
		DATE OF NAME CHANGE:	20011114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CYTOCLONAL PHARMACEUTICS INC /DE
		DATE OF NAME CHANGE:	19950503

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PAGANELLI JOHN A
		CENTRAL INDEX KEY:			0001236687

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-26648
		FILM NUMBER:		06753055

	BUSINESS ADDRESS:	
		STREET 1:		4 TAFT COURT
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
		BUSINESS PHONE:		585 586 8138
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v040253_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2006-04-03</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000944809</issuerCik>
        <issuerName>eXegenics Inc</issuerName>
        <issuerTradingSymbol>EXG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001236687</rptOwnerCik>
            <rptOwnerName>PAGANELLI JOHN A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1250 PITTSFORD-VICTOR ROAD, BUILDING 200</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 280</rptOwnerStreet2>
            <rptOwnerCity>PITTSFORD</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>14534</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Interim CEO, COB</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Option to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>.41</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2006-04-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>5000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-04-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2016-04-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <ownerSignature>
        <signatureName>/s/ John A. Paganelli</signatureName>
        <signatureDate>2006-04-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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