Note 16 - Leases (Details Textual)		6 Months Ended
Jan. 02, 2023 USD ($) a	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)
Operating Lease, Cost		$ 13,000,000	$ 9,200,000
Finance Lease, Interest Expense		600,000	1,300,000
Variable Lease, Cost		$ 700,000	$ 1,000,000
Office Space [Member] \| ModeX Therapeutics, Inc [Member]
Lessee, Operating Lease, Term of Contract (Year)	10 years
Area of Real Estate Property (Acre) \| a	33,056
Lessee, Operating Lease, Renewal Term (Year)	5 years
Operating Lease, Monthly Rent Expense	$ 243,500

Amount of monthly rent expense under operating lease.

No definition available.

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Namespace Prefix:	opk_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Area of a real estate property.

+ References

No definition available.

+ Details

Name:	us-gaap_AreaOfRealEstateProperty
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:areaItemType
Balance Type:	na
Period Type:	instant

- Definition

Amount of interest expense on finance lease liability.

+ References

Reference 1: http://www.xbrl.org/2003/role/exampleRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 55
-Paragraph 53
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479589/842-20-55-53

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
-Paragraph 4
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479041/842-20-45-4

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 4
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478964/842-20-50-4

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Term of lessee's operating lease renewal, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478964/842-20-50-3

+ Details

Name:	us-gaap_LesseeOperatingLeaseRenewalTerm
Namespace Prefix:	us-gaap_
Data Type:	xbrli:durationItemType
Balance Type:	na
Period Type:	instant

- Definition

Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:durationItemType
Balance Type:	na
Period Type:	instant

- Definition

Amount of single lease cost, calculated by allocation of remaining cost of lease over remaining lease term. Includes, but is not limited to, single lease cost, after impairment of right-of-use asset, calculated by amortization of remaining right-of-use asset and accretion of lease liability.

+ References

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Amount of variable lease cost, excluded from lease liability, recognized when obligation for payment is incurred for finance and operating leases.

+ References

+ Details

Name:	us-gaap_VariableLeaseCost
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Details

Name:	us-gaap_LeaseContractualTermAxis=opk_OfficeSpaceMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	dei_LegalEntityAxis=opk_ModexTherapeuticsIncMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: