Debt - Narrative (Details)		1 Months Ended				3 Months Ended	48 Months Ended
	Feb. 10, 2023 $ / shares	May 31, 2021 USD ($) shares	Feb. 28, 2019 USD ($) day $ / shares shares	Feb. 28, 2018 USD ($) $ / shares	Nov. 30, 2015 USD ($)	Mar. 31, 2023 USD ($) day institution shares	Dec. 31, 2016 USD ($) shares	Dec. 31, 2022 USD ($) institution shares	Mar. 31, 2022 USD ($)	Jan. 01, 2022 USD ($)	Dec. 31, 2021 USD ($)	Feb. 01, 2019 USD ($)	Jan. 30, 2013 USD ($)
Debt Instrument [Line Items]
Equity						$ 1,551,810,000		$ 1,561,648,000	$ 1,614,884,000		$ 1,685,126,000
Remaining principal						244,643,000		256,251,000
Credit line capacity						104,888,000
Goodwill						$ 597,380,000		$ 595,851,000		$ 633,874,000
Number of financial institutions | institution						13		13
BioReference
Debt Instrument [Line Items]
Net assets						$ 567,700,000
Goodwill						283,000,000
Intangible assets						$ 182,900,000
OPKO Health Europe
Debt Instrument [Line Items]
Weighted average interest rate (as a percent)						4.10%		3.50%
Retained Earnings
Debt Instrument [Line Items]
Equity						$ (1,841,190,000)		$ (1,822,923,000)	(1,549,951,000)		(1,511,976,000)
Additional Paid-in Capital
Debt Instrument [Line Items]
Equity						$ 3,424,589,000		3,421,872,000	$ 3,191,139,000		3,222,487,000
Cumulative Effect, Period of Adoption, Adjustment
Debt Instrument [Line Items]
Equity										21,600,000	(21,642,000)
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Debt Instrument [Line Items]
Equity										17,500,000	17,458,000
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Debt Instrument [Line Items]
Equity										$ (39,100,000)	$ (39,100,000)
Minimum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates (as a percent)						0.70%
Maximum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates (as a percent)						5.10%
Convertible Debt
Debt Instrument [Line Items]
Interest rate on notes payable (as a percent)			4.50%
Senior Notes
Debt Instrument [Line Items]
Remaining principal						$ 142,375,000		142,096,000
Line of Credit
Debt Instrument [Line Items]
Remaining principal						$ 11,318,000		$ 13,740,000
Weighted average interest rate (as a percent)						5.40%		5.40%
Convertible Senior Notes Due 2025 | Convertible Debt
Debt Instrument [Line Items]
Debt face amount			$ 200,000,000
Debt instrument, conversion ratio			0.2367424
Conversion price per share (in dollars per share) | $ / shares			$ 4.22
Converted debt amount		$ 55,400,000
Shares issued on converted debt (in shares) | shares		19,051,270
Shares issuable under debt agreement (in shares) | shares			30,000,000
Decrease in shares issuable under debt agreement (in shares) | shares		8,105,175
Outstanding shares on converted debt (in shares) | shares						21,144,825		21,144,825
Proceeds one-time nominal fee						$ 300,000
Remaining principal						$ 142,375,000		$ 142,096,000
Convertible Senior Notes Due 2025 | Convertible Debt | Redemption period one
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger (as a percent)			130.00%
Equivalent redemption price (as a percent)			100.00%
Convertible Senior Notes Due 2025 | Convertible Debt | Redemption period two
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger (as a percent)			98.00%
Convertible Senior Notes Due 2025 | Convertible Debt | Redemption period three
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger (as a percent)						130.00%
Equivalent redemption price (as a percent)						100.00%
Convertible Senior Notes Due 2025 | Convertible Debt | Minimum | Redemption period one
Debt Instrument [Line Items]
Number of trading days | day			20
Convertible Senior Notes Due 2025 | Convertible Debt | Minimum | Redemption period two
Debt Instrument [Line Items]
Number of trading days | day			5
Convertible Senior Notes Due 2025 | Convertible Debt | Minimum | Redemption period three
Debt Instrument [Line Items]
Number of trading days | day						20
Convertible Senior Notes Due 2025 | Convertible Debt | Maximum | Redemption period one
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day			30
Convertible Senior Notes Due 2025 | Convertible Debt | Maximum | Redemption period two
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day			5
Convertible Senior Notes Due 2025 | Convertible Debt | Maximum | Redemption period three
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day						30
5% Convertible Notes | Convertible Debt
Debt Instrument [Line Items]
Debt face amount				$ 55,000,000
Interest rate on notes payable (as a percent)				5.00%
Conversion price per share (in dollars per share) | $ / shares				$ 5.00
Debt instrument, term				5 years
Minimum conversion notice (in days)				30 days
Maximum conversion notice (in days)				60 days
Remaining principal						$ 68,953,000		68,275,000
2023 Convertible Notes | Convertible Debt
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger (as a percent)	25.00%
Conversion price per share (in dollars per share) | $ / shares	$ 1.66
Notes Due February 1, 2033 | Convertible Debt
Debt Instrument [Line Items]
Converted debt amount							$ 143,200,000
Notes Due February 1, 2033 | Convertible Debt | Common Stock
Debt Instrument [Line Items]
Shares issued on converted debt (in shares) | shares							21,539,873
Notes Due February 1, 2033 | Senior Notes
Debt Instrument [Line Items]
Debt face amount													$ 175,000,000
Interest rate on notes payable (as a percent)													3.00%
Notes Due February 1, 2033 | Notes
Debt Instrument [Line Items]
Debt repurchase amount												$ 28,800,000
Remaining principal						0		3,050,000				$ 3,000,000
Payment of the remaining outstanding balance						3,000,000
New Credit Agreement | Line of Credit | Revolving Credit Facility
Debt Instrument [Line Items]
Remaining principal						10,942,000		18,080,000
Credit line capacity					$ 75,000,000
Remaining borrowing capacity						16,200,000
Long-term line of credit, noncurrent						$ 10,900,000		$ 18,100,000
New Credit Agreement | Line of Credit | Revolving Credit Facility | 50% or more of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)					0.375%
New Credit Agreement | Line of Credit | Revolving Credit Facility | Less than or equal to 50% of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)					0.25%
New Credit Agreement | Line of Credit | Revolving Credit Facility | LIBOR
Debt Instrument [Line Items]
Basis spread on variable rate (as a percent)					2.50%
New Credit Agreement | Line of Credit | Revolving Credit Facility | LIBOR, First 12 Months
Debt Instrument [Line Items]
Basis spread on variable rate (as a percent)					0.75%
New Credit Agreement | Line of Credit | Revolving Credit Facility | LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities
Debt Instrument [Line Items]
Basis spread on variable rate (as a percent)					1.75%
New Credit Agreement | Line of Credit | Swingline
Debt Instrument [Line Items]
Credit line capacity					$ 20,000,000
New Credit Agreement | Line of Credit | Letter of Credit
Debt Instrument [Line Items]
Credit line capacity					$ 20,000,000