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Composition of Certain Financial Statement Captions - Changes in Goodwill (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Dec. 31, 2022
May 09, 2022
Jan. 01, 2022
Goodwill [Roll Forward]        
Goodwill $ 597,380 $ 595,851   $ 633,874
Cumulative impairment at January 1   (38,023)    
Acquisitions, dispositions and other (173)      
Foreign exchange and other 1,702      
Goodwill, ending balance 597,380 595,851   633,874
ModeX        
Goodwill [Roll Forward]        
Goodwill     $ 80,260  
Goodwill, ending balance     $ 80,260  
BioReference        
Goodwill [Roll Forward]        
Goodwill 283,000      
Goodwill, ending balance 283,000      
Pharmaceuticals | CURNA        
Goodwill [Roll Forward]        
Goodwill 0     4,827
Cumulative impairment at January 1   (4,827)    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 0     4,827
Pharmaceuticals | Rayaldee        
Goodwill [Roll Forward]        
Goodwill 83,090     81,786
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other 0      
Foreign exchange and other 1,304      
Goodwill, ending balance 83,090     81,786
Pharmaceuticals | FineTech        
Goodwill [Roll Forward]        
Goodwill 0     11,698
Cumulative impairment at January 1   (11,698)    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 0     11,698
Pharmaceuticals | ModeX        
Goodwill [Roll Forward]        
Goodwill 80,259     80,432
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other (173)      
Foreign exchange and other 0      
Goodwill, ending balance 80,259     80,432
Pharmaceuticals | OPKO Biologics        
Goodwill [Roll Forward]        
Goodwill 139,784     139,784
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 139,784     139,784
Pharmaceuticals | OPKO Chile        
Goodwill [Roll Forward]        
Goodwill 4,051     3,767
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other 0      
Foreign exchange and other 284      
Goodwill, ending balance 4,051     3,767
Pharmaceuticals | OPKO Health Europe        
Goodwill [Roll Forward]        
Goodwill 7,171     7,057
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other 0      
Foreign exchange and other 114      
Goodwill, ending balance 7,171     7,057
Pharmaceuticals | OPKO Mexico        
Goodwill [Roll Forward]        
Goodwill 0     100
Cumulative impairment at January 1   (100)    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 0     100
Pharmaceuticals | Transition Therapeutics        
Goodwill [Roll Forward]        
Goodwill 0     3,421
Cumulative impairment at January 1   (3,421)    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 0     3,421
Diagnostics | BioReference        
Goodwill [Roll Forward]        
Goodwill 283,025     283,025
Cumulative impairment at January 1   0    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance 283,025     283,025
Diagnostics | OPKO Diagnostics        
Goodwill [Roll Forward]        
Goodwill 0     17,977
Cumulative impairment at January 1   $ (17,977)    
Acquisitions, dispositions and other 0      
Foreign exchange and other 0      
Goodwill, ending balance $ 0     $ 17,977