Summary of Significant Accounting Policies (Details)			3 Months Ended
	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Mar. 31, 2023 USD ($) segment	Mar. 31, 2022 USD ($)	Jan. 01, 2022 USD ($)	Dec. 31, 2021 USD ($)
Summary of Significant Accounting Policies [Line Items]
Provision for inventory obsolescence			$ 1,400,000	$ 1,300,000
Goodwill, in-process research and development and other intangible assets acquired	$ 1,600,000,000	$ 1,600,000,000	1,600,000,000
Goodwill	597,380,000	595,851,000	597,380,000		$ 633,874,000
Net intangible assets other than goodwill	1,000,000,000	1,000,000,000	1,000,000,000
Intangible assets, net	803,616,000	823,520,000	803,616,000
In-process research and development	195,000,000	195,000,000	195,000,000
Amortization expense			21,474,000	22,025,000
Depreciation expense			5,000,000	5,800,000
Accrual related to uncertain tax positions included in income tax benefit	6,000,000		6,000,000
Allowance for credit losses	2,067,000	4,162,000	2,067,000
Provision related to current period sales			85,200	87,600
Equity-based compensation expense			$ 2,717,000	7,617,000
Number of reportable segments | segment			2
Foreign currency transaction gains			$ 1,000,000	1,100,000
Equity	1,551,810,000	1,561,648,000	1,551,810,000	1,614,884,000		$ 1,685,126,000
Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity	(1,841,190,000)	(1,822,923,000)	(1,841,190,000)	(1,549,951,000)		(1,511,976,000)
Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity	$ 3,424,589,000	$ 3,421,872,000	$ 3,424,589,000	3,191,139,000		3,222,487,000
Cumulative Effect, Period of Adoption, Adjustment
Summary of Significant Accounting Policies [Line Items]
Equity					21,600,000	(21,642,000)
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity					17,500,000	17,458,000
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity					$ (39,100,000)	$ (39,100,000)
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Intangible assets, net				590,200,000
Intangible assets, estimated useful lives			12 years
OPKO Biologics
Summary of Significant Accounting Policies [Line Items]
In-process research and development				$ 590,200,000
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			3 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			20 years
Credit Concentration Risk | Accounts Receivable | Federal and State Governments
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	14.00%	14.00%
Customer Concentration Risk | Accounts Receivable | Individual Patients
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	3.30%	2.90%
Software
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			3 years
Machinery, Medical and Other Equipment | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
Machinery, Medical and Other Equipment | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			8 years
Furniture and Fixtures | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
Furniture and Fixtures | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			12 years
Buildings and Improvements | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			10 years
Buildings and Improvements | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			40 years
Automobiles and Aircraft | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			3 years
Automobiles and Aircraft | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Net intangible assets other than goodwill	$ 195,000,000	$ 195,000,000	$ 195,000,000