Composition of Certain Financial Statement Captions - Changes in Goodwill (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	May 09, 2022	Jan. 01, 2022	Jan. 01, 2021	Dec. 31, 2020
Goodwill [Roll Forward]
Gross goodwill at January 1	$ 595,851	$ 520,601		$ 710,408	$ 718,625
Cumulative impairment at January 1		(38,023)				$ (38,023)
Acquisition and dispositions	(71,352)
Foreign exchange and other	(5,182)	(160,002)
Balance at December 31st	595,851	520,601		710,408	718,625
ModeX
Goodwill [Roll Forward]
Gross goodwill at January 1			$ 80,432
Balance at December 31st			$ 80,432
BioReference
Goodwill [Roll Forward]
Gross goodwill at January 1	283,000
Balance at December 31st	283,000
Pharmaceutical | CURNA
Goodwill [Roll Forward]
Gross goodwill at January 1	0	0		4,827	4,827
Cumulative impairment at January 1		(4,827)				(4,827)
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	0	0		4,827	4,827
Pharmaceutical | Rayaldee
Goodwill [Roll Forward]
Gross goodwill at January 1	81,786	86,554		86,554	93,418
Cumulative impairment at January 1		0				0
Acquisition and dispositions	0
Foreign exchange and other	(4,768)	(6,865)
Balance at December 31st	81,786	86,554		86,554	93,418
Pharmaceutical | FineTech
Goodwill [Roll Forward]
Gross goodwill at January 1	0	0		11,698	11,698
Cumulative impairment at January 1		(11,698)				(11,698)
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	0	0		11,698	11,698
Pharmaceutical | ModeX
Goodwill [Roll Forward]
Gross goodwill at January 1	80,432	0		0	0
Cumulative impairment at January 1						0
Acquisition and dispositions	80,432
Foreign exchange and other	0	0
Balance at December 31st	80,432	0		0	0
Pharmaceutical | OPKO Biologics
Goodwill [Roll Forward]
Gross goodwill at January 1	139,784	139,784		139,784	139,784
Cumulative impairment at January 1		0				0
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	139,784	139,784		139,784	139,784
Pharmaceutical | OPKO Chile
Goodwill [Roll Forward]
Gross goodwill at January 1	3,767	3,760		3,760	4,505
Cumulative impairment at January 1		0				0
Acquisition and dispositions	0
Foreign exchange and other	7	(745)
Balance at December 31st	3,767	3,760		3,760	4,505
Pharmaceutical | OPKO Health Europe
Goodwill [Roll Forward]
Gross goodwill at January 1	7,057	7,478		7,478	8,086
Cumulative impairment at January 1		0				0
Acquisition and dispositions	0
Foreign exchange and other	(421)	(608)
Balance at December 31st	7,057	7,478		7,478	8,086
Pharmaceutical | OPKO Mexico
Goodwill [Roll Forward]
Gross goodwill at January 1	0	0		100	100
Cumulative impairment at January 1		(100)				(100)
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	0	0		100	100
Pharmaceutical | Transition Therapeutics
Goodwill [Roll Forward]
Gross goodwill at January 1	0	0		3,421	3,421
Cumulative impairment at January 1		(3,421)				(3,421)
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	0	0		3,421	3,421
Diagnostics | BioReference
Goodwill [Roll Forward]
Gross goodwill at January 1	283,025	283,025		434,809	434,809
Cumulative impairment at January 1		0				0
Acquisition and dispositions	(151,784)
Foreign exchange and other	0	(151,784)
Balance at December 31st	283,025	283,025		434,809	434,809
Diagnostics | OPKO Diagnostics
Goodwill [Roll Forward]
Gross goodwill at January 1	0	0		17,977	17,977
Cumulative impairment at January 1		(17,977)				$ (17,977)
Acquisition and dispositions	0
Foreign exchange and other	0	0
Balance at December 31st	$ 0	$ 0		$ 17,977	$ 17,977