Composition of Certain Financial Statement Captions - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Jan. 01, 2022	Dec. 31, 2021	Jan. 01, 2021
Summary of Significant Accounting Policies [Line Items]
Goodwill	$ 595,851	$ 710,408	$ 520,601	$ 718,625
Intangible assets, net	823,520		321,683
In-process research and development	195,000		590,200
Detect Genomix
Summary of Significant Accounting Policies [Line Items]
Goodwill			$ 151,800
OPKO Biologics
Summary of Significant Accounting Policies [Line Items]
In-process research and development	$ 590,200
Covenants not to compete
Summary of Significant Accounting Policies [Line Items]
Useful life	5 years
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Intangible assets, net	$ 590,200
Intangible assets, estimated useful lives	12 years
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives	3 years
Minimum | Technologies
Summary of Significant Accounting Policies [Line Items]
Useful life	7 years
Minimum | Customer relationships
Summary of Significant Accounting Policies [Line Items]
Useful life	5 years
Minimum | Product registrations
Summary of Significant Accounting Policies [Line Items]
Useful life	7 years
Minimum | Trade names
Summary of Significant Accounting Policies [Line Items]
Useful life	5 years
Minimum | Other
Summary of Significant Accounting Policies [Line Items]
Useful life	9 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives	20 years
Maximum | Technologies
Summary of Significant Accounting Policies [Line Items]
Useful life	17 years
Maximum | Customer relationships
Summary of Significant Accounting Policies [Line Items]
Useful life	20 years
Maximum | Product registrations
Summary of Significant Accounting Policies [Line Items]
Useful life	10 years
Maximum | Trade names
Summary of Significant Accounting Policies [Line Items]
Useful life	10 years
Maximum | Other
Summary of Significant Accounting Policies [Line Items]
Useful life	13 years