Summary of Significant Accounting Policies (Details)			12 Months Ended
	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2022 USD ($) segment	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Jan. 01, 2022 USD ($)	Jan. 01, 2021 USD ($)	Dec. 31, 2019 USD ($)
Summary of Significant Accounting Policies [Line Items]
Provision for inventory obsolescence			$ 4,100,000	$ 6,500,000	$ 4,400,000
Goodwill, in-process research and development and other intangible assets acquired	$ 1,600,000,000	$ 1,400,000,000	1,600,000,000	1,400,000,000
Goodwill	595,851,000	520,601,000	595,851,000	520,601,000		$ 710,408,000	$ 718,625,000
Net intangible assets other than goodwill	1,000,000,000	1,100,000,000	1,000,000,000	1,100,000,000
Asset impairment charges			0	0
Intangible assets, net	823,520,000	321,683,000	823,520,000	321,683,000
In-process research and development	195,000,000	590,200,000	195,000,000	590,200,000
Amortization expense			87,784,000	50,278,000	56,391,000
Amortization expense in 2023	85,500,000		85,500,000
Amortization expense in 2024	85,300,000		85,300,000
Amortization expense in 2025	84,100,000		84,100,000
Amortization expense in 2026	82,800,000		82,800,000
Amortization expense in 2027	80,300,000		80,300,000
Depreciation expense			20,900,000	28,400,000	29,000,000
Accrual related to uncertain tax positions included in income tax benefit	6,000,000		6,000,000
Estimated tax exposure range			246,000,000
Allowance for credit losses	4,162,000	1,839,000	4,162,000	1,839,000
Provision related to current period sales			300,000	400,000	200,000
Equity-based compensation – employees and non-employees			$ 18,509,000	13,632,000	8,947,000
Number of reportable segments | segment			2
Foreign currency transaction gains (losses)			$ (1,800,000)	(1,400,000)	1,600,000
Equity	1,561,648,000	1,685,126,000	1,561,648,000	1,685,126,000	1,671,551,000			$ 1,614,759,000
Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity	(1,822,923,000)	(1,511,976,000)	(1,822,923,000)	(1,511,976,000)	(1,481,833,000)			(1,511,077,000)
Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity	$ 3,421,872,000	3,222,487,000	$ 3,421,872,000	3,222,487,000	$ 3,152,694,000			3,142,993,000
Cumulative Effect, Period of Adoption, Adjustment
Summary of Significant Accounting Policies [Line Items]
Equity		(21,642,000)		(21,642,000)		21,600,000		(1,342,000)
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity		17,458,000		17,458,000		17,500,000		$ (1,342,000)
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity		$ (39,100,000)		(39,100,000)		$ (39,100,000)
Federal and State Governments | Accounts Receivable | Credit Concentration Risk
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	14.00%	8.00%
States, Cities and Other Municipalities | Accounts Receivable | Geographic Concentration Risk
Summary of Significant Accounting Policies [Line Items]
Concentration percentage		4.10%
Individual Patients | Accounts Receivable | Customer Concentration Risk
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	2.90%	1.70%
Computer Software, Intangible Asset
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			3 years
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			3 years
Minimum | Machinery, Medical and Other Equipment
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
Minimum | Furniture and Fixtures
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
Minimum | Land, Buildings and Improvements
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			10 years
Minimum | Automobiles and aircraft
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			3 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			20 years
Maximum | Machinery, Medical and Other Equipment
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			8 years
Maximum | Furniture and Fixtures
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			12 years
Maximum | Land, Buildings and Improvements
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			40 years
Maximum | Automobiles and aircraft
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives			5 years
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Intangible assets, net	$ 590,200,000		$ 590,200,000
Intangible assets, estimated useful lives			12 years
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Net intangible assets other than goodwill	195,000,000	$ 590,200,000	$ 195,000,000	590,200,000
Detect Genomix
Summary of Significant Accounting Policies [Line Items]
Goodwill		$ 151,800,000		$ 151,800,000
OPKO Biologics
Summary of Significant Accounting Policies [Line Items]
In-process research and development	$ 590,200,000		$ 590,200,000