CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 153,191	$ 134,710
Accounts receivable, net	127,312	259,637
Inventory, net	74,060	86,502
Other current assets and prepaid expenses	39,962	27,170
Assets held for sale	0	314,994
Total current assets	394,525	823,013
Property, plant and equipment, net	82,879	79,727
Intangible assets, net	823,520	321,683
In-process research and development	195,000	590,200
Goodwill	595,851	520,601
Investments	28,080	10,729
Operating lease right-of-use assets	38,725	44,228
Other assets	8,679	9,534
Total assets	2,167,259	2,399,715
Current liabilities:
Accounts payable	66,993	82,040
Accrued expenses	98,269	193,493
Current maturities of operating leases	11,628	11,624
Current portion of convertible notes	3,050	0
Liabilities associated with assets held for sale	0	28,156
Current portion of lines of credit and notes payable	33,540	14,695
Total current liabilities	213,480	330,008
Operating lease liabilities	27,963	33,097
Convertible notes	210,371	187,935
Deferred tax liabilities	126,426	148,487
Other long-term liabilities, principally contract liabilities, contingent consideration and lines of credit	27,371	15,062
Total long-term liabilities	392,131	384,581
Total liabilities	605,611	714,589
Equity:
Common Stock - $0.01 par value, 1,000,000,000 shares authorized; 781,306,164 and 690,082,283 shares issued at December 31, 2022 and 2021, respectively	7,813	6,901
Treasury Stock, - 8,655,082 shares at December 31, 2022 and 2021, respectively	(1,791)	(1,791)
Additional paid-in capital	3,421,872	3,222,487
Accumulated other comprehensive loss	(43,323)	(30,495)
Accumulated deficit	(1,822,923)	(1,511,976)
Total shareholders’ equity	1,561,648	1,685,126
Total liabilities and equity	$ 2,167,259	$ 2,399,715