Debt - Narrative (Details)		1 Months Ended					9 Months Ended		12 Months Ended	48 Months Ended
	Jan. 30, 2013 USD ($)	May 31, 2021 USD ($) shares	Feb. 28, 2019 USD ($) day $ / shares shares	Feb. 28, 2018 USD ($) $ / shares	Nov. 30, 2015 USD ($)	Jan. 31, 2013	Sep. 30, 2022 USD ($) institution day shares	Sep. 30, 2021 USD ($)	Dec. 31, 2021 USD ($) institution shares	Dec. 31, 2016 USD ($) shares	Jun. 30, 2022 USD ($)	Jan. 01, 2022 USD ($)	Jun. 30, 2021 USD ($)	Dec. 31, 2020 USD ($)	Feb. 01, 2019 USD ($)
Debt Instrument [Line Items]
Converted debt amount							$ 0	$ 68,775,000
Loss on conversion of the 2025 Notes							0	11,111,000
Equity							1,629,068,000	1,765,567,000	$ 1,685,126,000		$ 1,718,799,000		$ 1,742,585,000	$ 1,671,551,000
Remaining principal							244,981,000		205,272,000
Credit line capacity							104,780,000
Goodwill							$ 573,499,000		$ 520,601,000			$ 710,408,000
Number of financial institutions | institution							13		11
Retained Earnings
Debt Instrument [Line Items]
Equity							$ (1,737,692,000)	(1,438,202,000)	$ (1,511,976,000)		(1,651,601,000)		(1,466,941,000)	(1,481,833,000)
Additional Paid-in Capital
Debt Instrument [Line Items]
Equity							3,418,763,000	$ 3,218,583,000	3,222,487,000		$ 3,413,556,000		$ 3,214,351,000	$ 3,152,694,000
Cumulative Effect, Period of Adoption, Adjustment
Debt Instrument [Line Items]
Equity									(21,642,000)			21,600,000
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Debt Instrument [Line Items]
Equity									17,458,000			17,500,000
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Debt Instrument [Line Items]
Equity									$ (39,100,000)			$ (39,100,000)
BioReference
Debt Instrument [Line Items]
Net assets							632,900,000
Goodwill							283,000,000
Intangible assets							$ 191,000,000
OPKO Health Europe
Debt Instrument [Line Items]
Weighted average interest rate							3.50%		3.50%
Minimum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates							0.70%
Maximum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates							5.10%
Line of Credit
Debt Instrument [Line Items]
Remaining principal							$ 14,493,000		$ 13,672,000
Weighted average interest rate							5.40%		5.40%
Convertible Debt
Debt Instrument [Line Items]
Interest rate on notes payable			4.50%
Convertible Debt | Convertible Senior Notes Due 2025
Debt Instrument [Line Items]
Debt face amount			$ 200,000,000
Debt instrument, conversion ratio			0.2367424
Conversion price per share (in dollars per share) | $ / shares			$ 4.22
Converted debt amount		$ 55,400,000
Shares issued on converted debt (in shares) | shares		19,051,270					21,144,825		21,144,825
Loss on conversion of the 2025 Notes		$ 11,100,000
Shares issuable under debt agreement (in shares) | shares			30,000,000
Decrease in shares issuable under debt agreement (in shares) | shares		8,105,175
Proceeds one-time nominal fee							$ 300,000
Remaining principal							$ 141,815,000		$ 119,360,000
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger			130.00%
Equivalent redemption price (as a percent)			100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Minimum
Debt Instrument [Line Items]
Number of trading days | day			20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day			30
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger			98.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Minimum
Debt Instrument [Line Items]
Number of trading days | day			5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day			5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger							130.00%
Equivalent redemption price (as a percent)							100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Minimum
Debt Instrument [Line Items]
Number of trading days | day							20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day							30
Convertible Debt | 5% Convertible Notes
Debt Instrument [Line Items]
Debt face amount				$ 55,000,000
Interest rate on notes payable				5.00%
Conversion price per share (in dollars per share) | $ / shares				$ 5.00
Debt instrument, term				5 years
Minimum conversion notice				30 days
Maximum conversion notice				60 days
Remaining principal							$ 67,582,000		65,525,000
Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Converted debt amount										$ 143,200,000
Senior Notes
Debt Instrument [Line Items]
Remaining principal							141,815,000		119,360,000
Senior Notes | Cumulative Effect, Period of Adoption, Adjustment | Accounting Standards Update 2020-06
Debt Instrument [Line Items]
Remaining principal									21,643,000
Senior Notes | Notes Due February 1, 2033
Debt Instrument [Line Items]
Debt face amount	$ 175,000,000
Interest rate on notes payable	3.00%
Equivalent redemption price (as a percent)	100.00%
Notes | Notes Due February 1, 2033
Debt Instrument [Line Items]
Equivalent redemption price (as a percent)						100.00%
Debt repurchase amount															$ 28,800,000
Remaining principal							3,050,000		3,050,000						$ 3,000,000
Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Remaining principal							7,357,000		0
Credit line capacity					$ 75,000,000
Remaining borrowing capacity							32,700,000
Long-term line of credit, noncurrent							$ 7,400,000		$ 0
Revolving Credit Facility | Line of Credit | New Credit Agreement | 50% or more of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)					0.375%
Revolving Credit Facility | Line of Credit | New Credit Agreement | Less than or equal to 50% of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)					0.25%
Swingline | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity					$ 20,000,000
Letter of Credit | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity					$ 20,000,000
LIBOR | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate					2.50%
LIBOR, First 12 Months | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate					0.75%
LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate					1.75%
Common Stock | Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Shares issued on converted debt (in shares) | shares										21,539,873