Composition of Certain Financial Statement Captions - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
	Mar. 31, 2022	Sep. 30, 2022	Jan. 01, 2022	Dec. 31, 2021
Acquired Finite-Lived Intangible Assets [Line Items]
Goodwill		$ 573,499	$ 710,408	$ 520,601
Intangible assets, net		835,136		321,683
In-process research and development		$ 195,000		590,200
Detect Genomix
Acquired Finite-Lived Intangible Assets [Line Items]
Goodwill				$ 151,800
OPKO Biologics
Acquired Finite-Lived Intangible Assets [Line Items]
In-process research and development	$ 590,200
Covenants not to compete
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		5 years
In Process Research and Development
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, net	$ 590,200
Intangible assets, estimated useful lives	12 years
Minimum
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, estimated useful lives		3 years
Minimum | Technologies
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		7 years
Minimum | Customer relationships
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		5 years
Minimum | Products
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		7 years
Minimum | Trade names
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		5 years
Minimum | Other
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		9 years
Maximum
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, estimated useful lives		20 years
Maximum | Technologies
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		17 years
Maximum | Customer relationships
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		20 years
Maximum | Products
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		10 years
Maximum | Trade names
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		10 years
Maximum | Other
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life		13 years