Composition of Certain Financial Statement Captions - Changes in Goodwill (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	May 09, 2022	Jan. 01, 2022	Dec. 31, 2021
Goodwill [Roll Forward]
Goodwill, beginning balance	$ 578,845		$ 710,408	$ 520,601
Cumulative impairment at January 1				(38,023)
Acquisitions and dispositions	(85,998)
Foreign exchange and other	(7,542)
Goodwill, ending balance	578,845		710,408	520,601
ModeX
Goodwill [Roll Forward]
Goodwill, beginning balance		$ 65,786
Goodwill, ending balance		$ 65,786
BioReference
Goodwill [Roll Forward]
Goodwill, beginning balance	283,000
Goodwill, ending balance	283,000
Pharmaceuticals | CURNA
Goodwill [Roll Forward]
Goodwill, beginning balance	0		4,827
Cumulative impairment at January 1				(4,827)
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	0		4,827
Pharmaceuticals | Rayaldee
Goodwill [Roll Forward]
Goodwill, beginning balance	79,902		86,554
Cumulative impairment at January 1				0
Acquisitions and dispositions
Foreign exchange and other	(6,652)
Goodwill, ending balance	79,902		86,554
Pharmaceuticals | FineTech
Goodwill [Roll Forward]
Goodwill, beginning balance	0		11,698
Cumulative impairment at January 1				(11,698)
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	0		11,698
Pharmaceuticals | ModeX
Goodwill [Roll Forward]
Goodwill, beginning balance	65,786		0
Cumulative impairment at January 1				0
Acquisitions and dispositions	65,786
Foreign exchange and other	0
Goodwill, ending balance	65,786		0
Pharmaceuticals | OPKO Biologics
Goodwill [Roll Forward]
Goodwill, beginning balance	139,784		139,784
Cumulative impairment at January 1				0
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	139,784		139,784
Pharmaceuticals | OPKO Chile
Goodwill [Roll Forward]
Goodwill, beginning balance	3,459		3,760
Cumulative impairment at January 1				0
Acquisitions and dispositions
Foreign exchange and other	(301)
Goodwill, ending balance	3,459		3,760
Pharmaceuticals | OPKO Health Europe
Goodwill [Roll Forward]
Goodwill, beginning balance	6,889		7,478
Cumulative impairment at January 1				0
Acquisitions and dispositions
Foreign exchange and other	(589)
Goodwill, ending balance	6,889		7,478
Pharmaceuticals | OPKO Mexico
Goodwill [Roll Forward]
Goodwill, beginning balance	0		100
Cumulative impairment at January 1				(100)
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	0		100
Pharmaceuticals | Transition Therapeutics
Goodwill [Roll Forward]
Goodwill, beginning balance	0		3,421
Cumulative impairment at January 1	(3,421)
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	0		3,421
Diagnostics | BioReference
Goodwill [Roll Forward]
Goodwill, beginning balance	283,025		434,809
Cumulative impairment at January 1				0
Acquisitions and dispositions	(151,784)
Foreign exchange and other	0
Goodwill, ending balance	283,025		434,809
Diagnostics | OPKO Diagnostics
Goodwill [Roll Forward]
Goodwill, beginning balance	0		17,977
Cumulative impairment at January 1				$ (17,977)
Acquisitions and dispositions
Foreign exchange and other	0
Goodwill, ending balance	$ 0		$ 17,977