Summary of Significant Accounting Policies (Details) $ in Thousands			3 Months Ended			6 Months Ended
	Jun. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) segment	Jun. 30, 2021 USD ($)	Jan. 01, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Summary of Significant Accounting Policies [Line Items]
Provision for inventory obsolescence			$ 300		$ 900	$ 1,000	$ 3,900
Goodwill, in-process research and development and other intangible assets acquired	$ 1,600,000	$ 1,400,000	1,600,000			1,600,000
Goodwill	578,845	520,601	578,845			578,845		$ 710,408
Net intangible assets other than goodwill	1,057,400	911,900	1,057,400			1,057,400
Intangible assets, net	862,409	321,683	862,409			862,409
In-process research and development	195,000	590,200	195,000			195,000
Amortization expense			22,793		12,574	44,818	25,151
Depreciation expense			5,200		8,000	11,000	15,400
Allowance for credit losses	6,801	1,839	6,801			6,801
Provision related to current period sales			100		300	200	600
Equity-based compensation expense			4,300		3,500	$ 11,900	6,100
Number of reportable segments | segment						2
Foreign currency transaction gains (losses)			800		(400)	$ 1,800	4,400
Equity	1,718,799	1,685,126	1,718,799	$ 1,614,884	1,742,585	1,718,799	1,742,585		$ 1,696,514	$ 1,671,551
Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity	(1,651,601)	(1,511,976)	(1,651,601)	(1,549,951)	(1,466,941)	(1,651,601)	(1,466,941)		(1,450,755)	(1,481,833)
Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity	$ 3,413,556	3,222,487	3,413,556	3,191,139	$ 3,214,351	$ 3,413,556	$ 3,214,351		$ 3,155,648	$ 3,152,694
Cumulative Effect, Period of Adoption, Adjustment
Summary of Significant Accounting Policies [Line Items]
Equity		(21,642)						21,600
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Summary of Significant Accounting Policies [Line Items]
Equity		17,458						17,500
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Summary of Significant Accounting Policies [Line Items]
Equity		(39,100)						$ (39,100)
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Intangible assets, net				$ 590,000
Intangible assets, estimated useful lives				12 years
Detect Genomix
Summary of Significant Accounting Policies [Line Items]
Goodwill		$ 151,800
OPKO Biologics
Summary of Significant Accounting Policies [Line Items]
In-process research and development				$ 590,000
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives						3 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives						20 years
Credit Concentration Risk | Accounts Receivable | Federal and State Governments
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	12.00%	6.00%
Geographic Concentration Risk | Accounts Receivable | States, Cities and Other Municipalities
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	3.90%	4.10%
Customer Concentration Risk | Accounts Receivable | Individual Patients
Summary of Significant Accounting Policies [Line Items]
Concentration percentage	2.30%	0.70%
Software
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						3 years
Machinery, Medical and Other Equipment | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						5 years
Machinery, Medical and Other Equipment | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						8 years
Furniture and Fixtures | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						5 years
Furniture and Fixtures | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						12 years
Buildings and Improvements | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						10 years
Buildings and Improvements | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						40 years
Automobiles and Aircraft | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						3 years
Automobiles and Aircraft | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, estimated useful lives						5 years
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Net intangible assets other than goodwill	$ 195,000	$ 590,200	$ 195,000			$ 195,000