<SEC-DOCUMENT>0000944809-22-000033-index.html : 20220603
<SEC-HEADER>0000944809-22-000033.hdr.sgml : 20220603
<ACCEPTANCE-DATETIME>20220603163738
ACCESSION NUMBER:		0000944809-22-000033
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20220603
DATE AS OF CHANGE:		20220603

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OPKO HEALTH, INC.
		CENTRAL INDEX KEY:			0000944809
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				752402409
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33528
		FILM NUMBER:		22995135

	BUSINESS ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137
		BUSINESS PHONE:		305-575-4181

	MAIL ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Opko Health, Inc.
		DATE OF NAME CHANGE:	20070621

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	eXegenics Inc
		DATE OF NAME CHANGE:	20040505

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXEGENICS INC
		DATE OF NAME CHANGE:	20011114
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>a2022proxydefa14a.htm
<DESCRIPTION>DEFA14A
<TEXT>
Document 1 - file: a2022proxydefa14a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>opkonaav4_pagex1.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: opkonaav4_pagex1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>opkonaav4_pagex2.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: opkonaav4_pagex2.jpg

</DOCUMENT>
</SEC-DOCUMENT>