Debt - Narrative (Details)			1 Months Ended					3 Months Ended	12 Months Ended	48 Months Ended
	Feb. 25, 2020 USD ($)	Jan. 30, 2013 USD ($)	May 31, 2021 USD ($) shares	Feb. 28, 2019 USD ($) day $ / shares shares	Feb. 28, 2018 USD ($) $ / shares	Nov. 30, 2015 USD ($)	Jan. 31, 2013	Mar. 31, 2022 USD ($) day institution shares	Dec. 31, 2021 USD ($) institution shares	Dec. 31, 2016 USD ($) shares	Jan. 01, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Feb. 01, 2019 USD ($)
Debt Instrument [Line Items]
Credit line capacity								$ 103,204,000
Amounts outstanding under line of credit								16,531,000	$ 13,672,000
Equity								1,614,884,000	1,685,126,000			$ 1,696,514,000	$ 1,671,551,000
Remaining principal								230,264,000	205,272,000
Goodwill								$ 519,052,000	$ 520,601,000		$ 710,408,000
Number of financial institutions | institution								13	13
Retained Earnings
Debt Instrument [Line Items]
Equity								$ (1,549,951,000)	$ (1,511,976,000)			(1,450,755,000)	(1,481,833,000)
Additional Paid-in Capital
Debt Instrument [Line Items]
Equity								3,191,139,000	3,222,487,000			$ 3,155,648,000	$ 3,152,694,000
Cumulative Effect, Period of Adoption, Adjustment
Debt Instrument [Line Items]
Equity									(21,642,000)		21,600,000
Cumulative Effect, Period of Adoption, Adjustment | Retained Earnings
Debt Instrument [Line Items]
Equity									17,458,000		17,500,000
Cumulative Effect, Period of Adoption, Adjustment | Additional Paid-in Capital
Debt Instrument [Line Items]
Equity									$ (39,100,000)		$ (39,100,000)
BioReference
Debt Instrument [Line Items]
Net assets								1,037,100,000
Goodwill								283,000,000
Intangible assets								$ 199,500,000
OPKO Health Europe
Debt Instrument [Line Items]
Weighted average interest rate								1.50%	1.50%
Minimum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates								0.70%
Maximum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates								3.80%
Line of Credit
Debt Instrument [Line Items]
Remaining principal								$ 16,531,000	$ 13,672,000
Weighted average interest rate								5.50%	5.40%
Convertible Debt
Debt Instrument [Line Items]
Interest rate on notes payable				4.50%
Convertible Debt | Convertible Senior Notes Due 2025
Debt Instrument [Line Items]
Debt face amount				$ 200,000,000
Debt instrument, conversion ratio				0.2367424
Conversion price per share (in dollars per share) | $ / shares				$ 4.22
Converted debt amount			$ 55,400,000
Shares issued on converted debt (in shares) | shares			19,051,270					21,144,825	21,144,825
Loss on conversion of the 2025 Notes			$ 11,100,000
Shares issuable under debt agreement (in shares) | shares				30,000,000
Decrease in shares issuable under debt agreement (in shares) | shares			8,105,175
Proceeds one-time nominal fee								$ 300,000
Equity component of convertible debt				$ 52,600,000
Effective interest rate (as a percent)								11.20%
Remaining principal								$ 141,267,000	$ 119,360,000
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger				130.00%
Equivalent redemption price				100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Minimum
Debt Instrument [Line Items]
Number of trading days | day				20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day				30
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger				98.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Minimum
Debt Instrument [Line Items]
Number of trading days | day				5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day				5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three
Debt Instrument [Line Items]
Convertible debt, threshold percentage of stock price trigger								130.00%
Equivalent redemption price								100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Minimum
Debt Instrument [Line Items]
Number of trading days | day								20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day								30
Convertible Debt | 5% Convertible Notes
Debt Instrument [Line Items]
Debt face amount					$ 55,000,000
Interest rate on notes payable					5.00%
Conversion price per share (in dollars per share) | $ / shares					$ 5.00
Debt instrument, term					5 years
Minimum conversion notice					30 days
Maximum conversion notice					60 days
Remaining principal								$ 66,203,000	65,525,000
Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Converted debt amount										$ 143,200,000
Senior Notes
Debt Instrument [Line Items]
Remaining principal								141,267,000	119,360,000
Senior Notes | Cumulative Effect, Period of Adoption, Adjustment | Accounting Standards Update 2020-06
Debt Instrument [Line Items]
Remaining principal									21,643,000
Senior Notes | Notes Due February 1, 2033
Debt Instrument [Line Items]
Debt face amount		$ 175,000,000
Interest rate on notes payable		3.00%
Equivalent redemption price		100.00%
Notes | Notes Due February 1, 2033
Debt Instrument [Line Items]
Equivalent redemption price							100.00%
Debt repurchase amount														$ 28,800,000
Remaining principal								3,050,000	$ 3,050,000					$ 3,000,000
Line of Credit | Unsecured Debt
Debt Instrument [Line Items]
Credit line capacity	$ 100,000,000
Amounts outstanding under line of credit								0
Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 75,000,000
Commitment fee (as a percent)	0.25%
Remaining borrowing capacity								64,800,000
Long-term line of credit, noncurrent								$ 0
Revolving Credit Facility | Line of Credit | New Credit Agreement | 50% or more of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)						0.375%
Revolving Credit Facility | Line of Credit | New Credit Agreement | Less than or equal to 50% of revolving commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)						0.25%
Swingline | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 20,000,000
Letter of Credit | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 20,000,000
LIBOR | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate						2.50%
LIBOR, First 12 Months | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate						0.75%
LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Basis spread on variable rate						1.75%
Common Stock | Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Shares issued on converted debt (in shares) | shares										21,539,873