Investments - Narrative (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended		12 Months Ended
	Sep. 14, 2021	Aug. 31, 2020	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Schedule of Equity Method Investments [Line Items]
Total assets of equity method investees			$ 2,306,858		$ 2,399,715
Total liabilities of equity method investees			691,974		714,589
Market value			3,600		4,500
Total revenues			329,219	$ 545,165
Transfer of intellectual property and other
Schedule of Equity Method Investments [Line Items]
Total revenues			5,962	$ 4,269
LeaderMed | LeaderMed Joint Venture | Corporate Joint Venture
Schedule of Equity Method Investments [Line Items]
Joint venture (in shares)	4,703
Ownership interest in joint venture (as a percent)	47.00%
LeaderMed | LeaderMed Joint Venture | Corporate Joint Venture | Transfer of intellectual property and other
Schedule of Equity Method Investments [Line Items]
Total revenues	$ 1,000		1,000
Equity Method Investment, Nonconsolidated Investee or Group of Investees
Schedule of Equity Method Investments [Line Items]
Total assets of equity method investees			222,100		223,600
Total liabilities of equity method investees			37,600		37,900
Net losses of equity method investees			$ 19,000		$ 69,400
Pharmsynthez
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			9.00%
Cocrystal
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			3.00%
Number of shares into which warrants may be converted (in shares)			33,000
Non-Invasive Monitoring Systems, Inc.
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			1.00%
Neovasc
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			1.00%
InCellDx, Inc
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			29.00%
Number of shares into which warrants may be converted (in shares)			700,000
BioCardia, Inc.
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			1.00%
Equity security investments (as a percent)			1.00%
Number of shares into which warrants may be converted (in shares)			47,000		47,000
Xenetic Biosciences, Inc.
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			1.00%
Phio Pharmaceuticals
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			0.01%
VBI Vaccines Inc
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			1.00%
ChromaDex
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			0.10%
Eloxx Pharmaceuticals
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			1.00%
CAMP4
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			5.00%
HealthSnap
Schedule of Equity Method Investments [Line Items]
Equity security investments (as a percent)			7.00%
Detect Genomix | Variable Interest Entity, Not Primary Beneficiary
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)		49.00%
Additional investment in equity method investment		$ 245
Zebra | Variable Interest Entity, Not Primary Beneficiary
Schedule of Equity Method Investments [Line Items]
Equity method investments (as a percent)			29.00%
Series A Preferred Stock | Zebra | Variable Interest Entity, Not Primary Beneficiary
Schedule of Equity Method Investments [Line Items]
Investment owned (in shares)			1,260,000
Restricted Stock | Zebra | Variable Interest Entity, Not Primary Beneficiary
Schedule of Equity Method Investments [Line Items]
Shares received as a gift (in shares)			900,000