Composition of Certain Financial Statement Captions - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Jan. 01, 2022	Dec. 31, 2021
Acquired Finite-Lived Intangible Assets [Line Items]
Goodwill	$ 519,052	$ 710,408	$ 520,601
Intangible assets, net	890,498		321,683
In-Process Research and Development	0		(590,200)
Detect Genomix
Acquired Finite-Lived Intangible Assets [Line Items]
Goodwill	151,800		$ 151,800
OPKO Biologics
Acquired Finite-Lived Intangible Assets [Line Items]
In-Process Research and Development	$ 590,000
Covenants not to compete
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	5 years
In Process Research and Development
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, net	$ 590,000
Intangible assets, estimated useful lives	12 years
Minimum
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, estimated useful lives	3 years
Minimum | Technologies
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	7 years
Minimum | Customer relationships
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	7 years
Minimum | Products
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	7 years
Minimum | Trade names
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	5 years
Minimum | Other
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	9 years
Maximum
Acquired Finite-Lived Intangible Assets [Line Items]
Intangible assets, estimated useful lives	20 years
Maximum | Technologies
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	17 years
Maximum | Customer relationships
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	20 years
Maximum | Products
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	10 years
Maximum | Trade names
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	10 years
Maximum | Other
Acquired Finite-Lived Intangible Assets [Line Items]
Useful life	13 years