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Contractual interest rate for funds borrowed, under the debt agreement.

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The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.

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The carrying value as of the balance sheet date of the current and noncurrent portions of long-term obligations drawn from a line of credit, which is a bank's commitment to make loans up to a specific amount. Examples of items that might be included in the application of this element may consist of letters of credit, standby letters of credit, and revolving credit arrangements, under which borrowings can be made up to a maximum amount as of any point in time conditional on satisfaction of specified terms before, as of and after the date of drawdowns on the line. Includes short-term obligations that would normally be classified as current liabilities but for which (a) postbalance sheet date issuance of a long term obligation to refinance the short term obligation on a long term basis, or (b) the enterprise has entered into a financing agreement that clearly permits the enterprise to refinance the short-term obligation on a long term basis and the following conditions are met (1) the agreement does not expire within 1 year and is not cancelable by the lender except for violation of an objectively determinable provision, (2) no violation exists at the BS date, and (3) the lender has entered into the financing agreement is expected to be financially capable of honoring the agreement.

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Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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The fee, expressed as a percentage of the line of credit facility, for available but unused credit capacity under the credit facility.

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The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence.

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The cash inflow associated with the amount received from holders exercising their stock warrants.

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Amount of transactions with related party during the financial reporting period.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Amount of cash outflow for payment of an obligation from a lender, including but not limited to, letter of credit, standby letter of credit and revolving credit arrangements.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Percentage of the Variable Interest Entity's (VIE) voting interest owned by (or beneficial interest in) the reporting entity (directly or indirectly).

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Related Party Transactions (Details)				1 Months Ended					3 Months Ended	12 Months Ended
Related Party Transactions (Details)	Feb. 25, 2020 USD ($)	Oct. 29, 2019 USD ($) $ / shares shares	Feb. 20, 2019 USD ($)	Aug. 31, 2020 USD ($)	Nov. 30, 2019 USD ($) $ / shares shares	Mar. 31, 2019 USD ($)	Feb. 28, 2019 USD ($)	Nov. 30, 2016 USD ($)	Mar. 31, 2019 USD ($) shares	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Aug. 01, 2019 USD ($) ft²	Mar. 01, 2019 shares	Nov. 08, 2018 USD ($)	Nov. 30, 2015 USD ($)
Related Party Transaction [Line Items]
Credit line capacity										$ 103,359,000
Amounts outstanding under line of credit										13,672,000	$ 22,954,000
Repayments of line of credit										1,695,956,000	$ 1,143,698,000	$ 359,322,000
Reverse stock split ratio												0.01
Detect Genomix \| Variable Interest Entity, Not Primary Beneficiary
Related Party Transaction [Line Items]
Payments in equity method investment				$ 245,000
Equity method investments (as a percent)				49.00%
Detect Genomix \| Mednax Services, Inc. \| Variable Interest Entity, Not Primary Beneficiary
Related Party Transaction [Line Items]
Payments in equity method investment										$ 255,000
Equity method investments (as a percent)				51.00%
Pharmsynthez
Related Party Transaction [Line Items]
Equity method investments (as a percent)										9.00%
Zebra
Related Party Transaction [Line Items]
Stock ownership (as a percent)										29.00%
Zebra \| Variable Interest Entity, Not Primary Beneficiary
Related Party Transaction [Line Items]
Equity method investments (as a percent)										29.00%	29.00%
Neovasc
Related Party Transaction [Line Items]
Equity method investments (as a percent)										1.00%
ChromaDex Corporation
Related Party Transaction [Line Items]
Equity security investments (as a percent)										0.10%
Cocrystal Pharma
Related Party Transaction [Line Items]
Equity method investments (as a percent)										3.00%
NIMS
Related Party Transaction [Line Items]
Equity method investments (as a percent)										1.00%
Eloxx Pharmaceuticals
Related Party Transaction [Line Items]
Equity security investments (as a percent)										2.00%
BioCardia, Inc.
Related Party Transaction [Line Items]
Equity method investments (as a percent)										1.00%
LeaderMed
Related Party Transaction [Line Items]
Stock ownership (as a percent)										47.00%
InCellDx, Inc
Related Party Transaction [Line Items]
Equity method investments (as a percent)										29.00%
Dr Frost and Mr Pfenniger \| Museum of Science, Inc
Related Party Transaction [Line Items]
Future contributions to related party								$ 1,000,000
Future contributions to related party, period								4 years
Real Estate Holdings LLC
Related Party Transaction [Line Items]
Area of real estate property (in square feet) \| ft²													29,500
Monthly operating lease payment in year one													$ 89,000
Monthly operating lease payment in year five													$ 101,000
Federal Trade Commission Filing Fees \| Chief Technical Officer
Related Party Transaction [Line Items]
Filing fee				$ 125,000		$ 125,000
Federal Trade Commission Filing Fees \| Chief Executive Officer
Related Party Transaction [Line Items]
Filing fee				$ 280,000			$ 280,000
OPKO Transaction Shares \| Affiliated Entity \| Xenetic Biosciences, Inc.
Related Party Transaction [Line Items]
Shares issued (in shares) \| shares														164,062
Shares Received Upon Closing of Xenetic Transaction \| Director
Related Party Transaction [Line Items]
Shares received upon closing of transaction (in shares) \| shares														31,240
Reimbursement Of Travel Expense \| Dr Frost
Related Party Transaction [Line Items]
Reimbursement paid to related party for travel										$ 105,000	$ 156,000	$ 328,000
Series A Warrant \| Neovasc
Related Party Transaction [Line Items]
Proceeds from exercise of warrants									$ 1,200,000
Series C Warrant \| Neovasc
Related Party Transaction [Line Items]
Exercise of warrant number of securities received (in shares) \| shares									22,660
Line of Credit \| Unsecured Debt
Related Party Transaction [Line Items]
Credit line capacity	$ 100,000,000														$ 60,000,000
Amounts outstanding under line of credit										$ 0
Interest rate of notes payable (as a percent)															10.00%
Line of Credit \| Unsecured Debt \| Dr Frost
Related Party Transaction [Line Items]
Repayments of line of credit			$ 28,800,000
Revolving Credit Facility \| Line of Credit \| New Credit Agreement
Related Party Transaction [Line Items]
Credit line capacity																$ 75,000,000
Commitment fee (as a percent)	0.25%
IPO
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares		50,000,000
Price per share of common stock (in dollars per share) \| $ / shares		$ 1.50
Net proceeds in transaction		$ 70,000,000
Over-Allotment Option
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares					4,227,749
Price per share of common stock (in dollars per share) \| $ / shares					$ 1.50
Net proceeds in transaction					$ 6,000,000
Members of Senior Management \| IPO
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares		2,415,000