Income Taxes - Schedule of Difference in Federal and Effective Tax Rate (Details)	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Summary of difference between the federal statutory tax rate and the effective tax rate
Federal statutory rate	21.00%	21.00%	21.00%
State income taxes, net of federal benefit	(7.90%)	17.40%	2.80%
Foreign income tax	21.60%	53.70%	(6.60%)
Income Tax Refunds	6.10%	(0.60%)	0.00%
Research and development tax credits	2.30%	(1.00%)	0.30%
Valuation allowance	235.40%	227.70%	(17.90%)
Rate change effect	(40.50%)	11.40%	0.40%
Non-deductible items	(67.00%)	5.20%	(1.70%)
Unrecognized tax benefits	11.30%	(5.00%)	0.00%
Impairments	0.00%	0.00%	(1.60%)
IPR&D benefit	0.00%	(309.60%)	0.00%
Stock options excess tax benefit	(3.80%)	10.60%	0.40%
Imputed interest	(6.30%)	2.50%	0.50%
Investment in subsidiaries	(287.60%)	0.00%	0.00%
Other	9.70%	3.20%	0.10%
Total	(105.70%)	36.50%	(2.30%)

Effective Income Tax Rate Reconciliation, Imputed Interest, Percent

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Effective Income Tax Rate Reconciliation, Income Tax Refund, Percent

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Effective Income Tax Rate Reconciliation, Nondeductible Expense, In-Process Research and Development, Percent

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Effective Income Tax Rate Reconciliation, Unrecognized Tax Benefits, Percent

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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-Publisher FASB
-Name Accounting Standards Codification
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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to equity in earnings (loss) of unconsolidated subsidiaries exempt from income taxes.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to statutory income tax expense (benefit) outside of the country of domicile.

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Percentage of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to expense for award under share-based payment arrangement. Excludes expense determined to be nondeductible upon grant or after for award under share-based payment arrangement.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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