Debt - Narrative (Details)			1 Months Ended					12 Months Ended			48 Months Ended
	Feb. 25, 2020 USD ($)	Nov. 05, 2015	May 31, 2021 USD ($) shares	Feb. 28, 2019 USD ($)	Feb. 28, 2018 USD ($) $ / shares	Nov. 30, 2015 USD ($)	Jan. 31, 2013 USD ($)	Dec. 31, 2021 USD ($) day institution $ / shares shares	Dec. 31, 2020 USD ($) shares	Dec. 31, 2019 USD ($)	Dec. 31, 2016 USD ($) shares	Jan. 01, 2021 USD ($)	Jan. 01, 2020 USD ($)	Feb. 01, 2019 USD ($)	Dec. 31, 2018 USD ($)	Nov. 08, 2018 USD ($)
Debt Instrument [Line Items]
Credit line capacity								$ 103,359,000
Loss on conversion of the 2025 Notes								11,111,000	$ 0	$ 0
Net assets								1,685,126,000	1,671,551,000	$ 1,614,759,000					$ 1,791,291,000
Goodwill								$ 520,601,000	$ 680,602,000			$ 718,625,000	$ 709,963,000
Number of financial institutions | institution								11
BioReference Laboratories, Inc.
Debt Instrument [Line Items]
Net assets								$ 1,103,600,000
Goodwill								283,000,000
Intangible assets								$ 204,400,000
OPKO Health Europe
Debt Instrument [Line Items]
Weighted average interest rate (as a percent)								1.50%	2.90%
Minimum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates (as a percent)								0.70%
Maximum | OPKO Health Europe
Debt Instrument [Line Items]
Variable interest rates (as a percent)								3.80%
Line of Credit
Debt Instrument [Line Items]
Weighted average interest rate (as a percent)								5.40%	4.90%
Convertible Debt
Debt Instrument [Line Items]
Interest rate of notes payable (as a percent)				4.50%
Convertible Debt | Convertible Senior Notes Due 2025
Debt Instrument [Line Items]
Debt face amount				$ 200,000,000
Conversion ratio				0.2367424
Conversion price (in dollars per share) | $ / shares								$ 4.22
Convertible notes, conversion			$ 55,400,000
Convertible debt, stock issued from conversion (in shares) | shares			19,051,270					21,144,825	29,250,000
Loss on conversion of the 2025 Notes			$ 11,100,000
Maximum shares of common stock to be loaned to affiliates (in shares) | shares								30,000,000
Decrease in shares issuable under debt agreement (in shares) | shares			8,105,175
One-time nominal fee for newly issued shares								$ 300,000
Valuation of equity component at issue date								$ 52,600,000
Effective interest rate (as a percent)								11.20%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one
Debt Instrument [Line Items]
Convertible debt, stock price trigger threshold (as a percent)								130.00%
Equivalent redemption price (as a percent)								100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Minimum
Debt Instrument [Line Items]
Threshold trading days | day								20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period one | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day								30
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two
Debt Instrument [Line Items]
Convertible debt, stock price trigger threshold (as a percent)								98.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Minimum
Debt Instrument [Line Items]
Threshold trading days | day								5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period two | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day								5
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three
Debt Instrument [Line Items]
Convertible debt, stock price trigger threshold (as a percent)								130.00%
Equivalent redemption price (as a percent)								100.00%
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Minimum
Debt Instrument [Line Items]
Threshold trading days | day								20
Convertible Debt | Convertible Senior Notes Due 2025 | Redemption period three | Maximum
Debt Instrument [Line Items]
Number of consecutive trading days applicable conversion price | day								30
Convertible Debt | 5% Convertible Notes
Debt Instrument [Line Items]
Debt face amount					$ 55,000,000
Interest rate of notes payable (as a percent)					5.00%
Conversion price (in dollars per share) | $ / shares					$ 5.00
Note maturity term					5 years
Conversion notice threshold minimum (in days)					30 days
Conversion notice threshold maximum (in days)					60 days
Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Convertible notes, conversion											$ 143,200,000
Notes | Notes Due February 1, 2033
Debt Instrument [Line Items]
Debt face amount							$ 175,000,000
Interest rate of notes payable (as a percent)							3.00%
Equivalent redemption price (as a percent)							100.00%
Debt repurchase amount														$ 28,800,000
Equity securities | Convertible Debt | Notes Due February 1, 2033
Debt Instrument [Line Items]
Convertible debt, stock issued from conversion (in shares) | shares											21,539,873
Line of Credit | Unsecured Debt
Debt Instrument [Line Items]
Credit line capacity	$ 100,000,000															$ 60,000,000
Interest rate of notes payable (as a percent)																10.00%
Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 75,000,000
Commitment fee (as a percent)	0.25%
Remaining borrowing capacity								$ 64,800,000
Line of credit								$ 0	$ 7,100,000
Revolving Credit Facility | Line of Credit | New Credit Agreement | Line Of Credit Facility, 50% Or More Of Revolving Commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)						0.375%
Revolving Credit Facility | Line of Credit | New Credit Agreement | Line Of Credit Facility, Less Than or Equal To 50% Of Revolving Commitment
Debt Instrument [Line Items]
Commitment fee (as a percent)						0.25%
Bridge Loan | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 20,000,000
Letter of Credit | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Credit line capacity						$ 20,000,000
LIBOR | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Estimated credit spread (as a percent)		2.50%
LIBOR, First 12 Months | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Estimated credit spread (as a percent)		0.75%
LIBOR, First 12 Months, Adjusted for Eurocurrency Liabilities | Revolving Credit Facility | Line of Credit | New Credit Agreement
Debt Instrument [Line Items]
Estimated credit spread (as a percent)		1.75%