Summary of Significant Accounting Policies - Narrative (Details)			12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2021 USD ($) segment	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Jan. 01, 2021 USD ($)	Jan. 01, 2020 USD ($)
Summary of Significant Accounting Policies [Line Items]
Inventory write-down			$ 6,500,000	$ 4,400,000	$ 2,300,000
Goodwill and intangible assets	$ 1,400,000,000	$ 1,700,000,000	1,400,000,000	1,700,000,000
Goodwill	520,601,000	680,602,000	520,601,000	680,602,000		$ 718,625,000	$ 709,963,000
Net intangible assets other than goodwill	911,900,000	1,100,000,000	911,900,000	1,100,000,000
Asset impairment charges			0	0	92,399,000
Goodwill impairment loss			0	0	26,200,000
Amortization of intangible assets			50,278,000	56,391,000	64,783,000
Amortization expense in 2022	38,100,000		38,100,000
Amortization expense in 2023	37,000,000.0		37,000,000.0
Amortization expense in 2024	36,800,000		36,800,000
Amortization expense in 2025	35,500,000		35,500,000
Amortization expense in 2026	34,200,000		34,200,000
Depreciation			28,400,000	29,000,000	29,000,000
Accrual related to uncertain tax positions included in income tax benefit	3,200,000		3,200,000
Estimated tax exposure range			66,000,000
Allowance for doubtful accounts	1,839,000	$ 2,055,000	1,839,000	2,055,000
Provision for doubtful accounts			400,000	200,000	500,000
Equity-based compensation expense for continuing operations			$ 13,632,000	8,947,000	13,421,000
Number of reportable segments | segment			2
Foreign currency transaction gains			$ (1,400,000)	$ 1,600,000	400,000
Detect Genomix
Summary of Significant Accounting Policies [Line Items]
Goodwill	$ 151,800,000		$ 151,800,000
OPKO Biologics
Summary of Significant Accounting Policies [Line Items]
Excess of estimated fair value over carrying amount (as a percent)	19.00%		19.00%
Minimum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			3 years
Maximum
Summary of Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			20 years
Computer Software, Intangible Asset
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			3 years
Machinery, Medical and Other Equipment | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			5 years
Machinery, Medical and Other Equipment | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			8 years
Furniture and Fixtures | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			5 years
Furniture and Fixtures | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			12 years
Land, Buildings and Improvements | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			10 years
Land, Buildings and Improvements | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			40 years
Automobiles and Aircraft | Minimum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			3 years
Automobiles and Aircraft | Maximum
Summary of Significant Accounting Policies [Line Items]
Property, plant and equipment, useful life			5 years
Accounts Receivable | Credit Concentration Risk | Federal and State Governments
Summary of Significant Accounting Policies [Line Items]
Percentage of revenue contributed by customer			8.00%	6.00%
Accounts Receivable | Geographic Concentration Risk | States, Cities and Other Municipalities
Summary of Significant Accounting Policies [Line Items]
Percentage of revenue contributed by customer	4.10%	6.30%
Accounts Receivable | Customer Concentration Risk | Individual Patients
Summary of Significant Accounting Policies [Line Items]
Percentage of revenue contributed by customer			1.70%	0.70%
In Process Research and Development
Summary of Significant Accounting Policies [Line Items]
Net intangible assets other than goodwill	$ 590,200,000	$ 590,200,000	$ 590,200,000	$ 590,200,000
Impairment of assets					44,800,000
Trademarks
Summary of Significant Accounting Policies [Line Items]
Impairment of assets					$ 20,700,000