Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 134,710	$ 72,211
Accounts receivable, net	259,637	286,314
Inventory, net	86,502	132,341
Other current assets and prepaid expenses	27,170	32,313
Assets held for sale	314,994	0
Total current assets	823,013	523,179
Property, plant and equipment, net	79,727	140,554
Intangible assets, net	321,683	475,002
In-process research and development	590,200	590,200
Goodwill	520,601	680,602
Investments	10,729	15,731
Operating lease right-of-use assets	44,228	37,735
Other assets	9,534	10,060
Total assets	2,399,715	2,473,063
Current liabilities:
Accounts payable	82,040	100,883
Accrued expenses	193,493	240,869
Current maturities of operating leases	11,624	9,028
Liabilities associated with assets held for sale	28,156	0
Current portion of lines of credit and notes payable	14,695	24,703
Total current liabilities	330,008	375,483
Operating lease liabilities	33,097	29,760
Convertible notes	187,935	221,989
Deferred tax liabilities	148,487	137,208
Other long-term liabilities, principally contract liabilities, contingent consideration and lines of credit	15,062	37,072
Total long-term liabilities	384,581	426,029
Total liabilities	714,589	801,512
Equity:
Common Stock - $0.01 par value, 1,000,000,000 shares authorized at December 31, 2021 and 2020, respectively; 690,082,283 and 670,585,576 shares issued at December 31, 2021 and 2020, respectively	6,901	6,706
Treasury Stock, - 8,655,082 and 549,907 shares at December 31, 2021 and 2020, respectively	(1,791)	(1,791)
Additional paid-in capital	3,222,487	3,152,694
Accumulated other comprehensive loss	(30,495)	(4,225)
Accumulated deficit	(1,511,976)	(1,481,833)
Total shareholders’ equity	1,685,126	1,671,551
Total liabilities and equity	$ 2,399,715	$ 2,473,063