<SEC-DOCUMENT>0000944809-22-000002-index.html : 20220118
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<ACCEPTANCE-DATETIME>20220118171041
ACCESSION NUMBER:		0000944809-22-000002
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		14
CONFORMED PERIOD OF REPORT:	20220114
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20220118
DATE AS OF CHANGE:		20220118

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OPKO HEALTH, INC.
		CENTRAL INDEX KEY:			0000944809
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				752402409
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33528
		FILM NUMBER:		22535902

	BUSINESS ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137
		BUSINESS PHONE:		305-575-4181

	MAIL ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Opko Health, Inc.
		DATE OF NAME CHANGE:	20070621

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	eXegenics Inc
		DATE OF NAME CHANGE:	20040505

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXEGENICS INC
		DATE OF NAME CHANGE:	20011114
</SEC-HEADER>
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<FILENAME>opk-20220114.htm
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<TEXT>
Document 1 - file: opk-20220114.htm

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<DESCRIPTION>EX-2.1
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Document 2 - file: ex2-1mergeragmt.htm

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<DESCRIPTION>EX-10.1
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Document 3 - file: ex10-1shagmt.htm

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<SEQUENCE>4
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<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA DOCUMENT
<TEXT>
Document 4 - file: opk-20220114.xsd

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<FILENAME>opk-20220114_lab.xml
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<TEXT>
Document 5 - file: opk-20220114_lab.xml

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<SEQUENCE>6
<FILENAME>opk-20220114_pre.xml
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<TEXT>
Document 6 - file: opk-20220114_pre.xml

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<TEXT>
Document 7 - file: R1.htm

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<FILENAME>Financial_Report.xlsx
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<TEXT>
Document 9 - file: Financial_Report.xlsx

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Document 10 - file: Show.js

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<SEQUENCE>11
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Document 11 - file: report.css

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<TYPE>XML
<SEQUENCE>12
<FILENAME>FilingSummary.xml
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Document 12 - file: FilingSummary.html

Document 12 - RAW XML: FilingSummary.xml

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<DOCUMENT>
<TYPE>JSON
<SEQUENCE>14
<FILENAME>MetaLinks.json
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<TEXT>
Document 14 - file: MetaLinks.json

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<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>15
<FILENAME>0000944809-22-000002-xbrl.zip
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<TEXT>
Document 15 - file: 0000944809-22-000002-xbrl.zip

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