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Area of a real estate property.

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Face (par) amount of debt instrument at time of issuance.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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Related Party Transactions - Narrative (Details)				1 Months Ended										3 Months Ended	12 Months Ended
Related Party Transactions - Narrative (Details)	Oct. 29, 2019 USD ($) $ / shares shares	Feb. 20, 2019 USD ($)	Nov. 08, 2018 USD ($) $ / shares shares	Nov. 30, 2019 USD ($) $ / shares shares	Mar. 31, 2019 USD ($)	Feb. 28, 2019 USD ($)	May 31, 2018 shares	Apr. 30, 2018 shares	Feb. 28, 2018 USD ($)	Nov. 30, 2017 USD ($) shares	Jul. 31, 2017 USD ($) shares	May 31, 2017 USD ($) shares	Apr. 30, 2017 USD ($) shares	Mar. 31, 2019 USD ($) shares	Dec. 31, 2019 USD ($) shares	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Aug. 01, 2019 USD ($) ft²	Mar. 01, 2019 shares	Nov. 30, 2016 USD ($)
Related Party Transaction [Line Items]
Private placement agreement number of shares (in shares) \| shares			26,500,000
Private placement agreement price per share (in dollars per share) \| $ / shares			$ 3.49
Private placement agreement value of shares			$ 92,500,000
Credit line capacity															$ 97,756,000
Repayments of line of credit															359,322,000	$ 34,681,000	$ 33,510,000
Investments in investees															$ 1,200,000	1,000,000	$ 9,625,000
Reverse stock split ratio																	0.083
Pharmsynthez
Related Party Transaction [Line Items]
Investment ownership percentage															9.00%
Zebra
Related Party Transaction [Line Items]
Investment ownership percentage															29.00%
Neovasc
Related Party Transaction [Line Items]
Investment ownership percentage															4.00%
Payments in equity method investment										$ 3,000,000.0
Neovasc \| Equity securities
Related Party Transaction [Line Items]
Equity method shares purchased in period (in shares) \| shares										20,547
ChromaDex Corporation
Related Party Transaction [Line Items]
Equity security investments, ownership percentage															0.10%
MabVax
Related Party Transaction [Line Items]
Equity security investments, ownership percentage															1.00%
Investments in investees											$ 100,000	$ 500,000
MabVax \| Series G Preferred Stock
Related Party Transaction [Line Items]
Available-for-sale securities shares purchased in period (in shares) \| shares											50,714
MabVax \| Series L Preferred Stock
Related Party Transaction [Line Items]
Available-for-sale securities shares purchased in period (in shares) \| shares												1,667
MabVax \| Series I Preferred Stock
Related Party Transaction [Line Items]
Available-for-sale securities shares purchased in period (in shares) \| shares												107,607
Cocrystal Pharma
Related Party Transaction [Line Items]
Investment ownership percentage															7.00%
NIMS
Related Party Transaction [Line Items]
Investment ownership percentage															1.00%
BioCardia, Inc.
Related Party Transaction [Line Items]
Investment ownership percentage															3.00%
Warrants to purchase common shares (in shares) \| shares															47,000
Cocrystal
Related Party Transaction [Line Items]
Payments in equity method investment													$ 1,000,000.0
Warrants to purchase common shares (in shares) \| shares															33,000
Cocrystal \| Equity securities
Related Party Transaction [Line Items]
Equity method shares purchased in period (in shares) \| shares													138,889
InCellDx, Inc
Related Party Transaction [Line Items]
Investment ownership percentage															29.00%
Eloxx Pharmaceuticals
Related Party Transaction [Line Items]
Equity security investments, ownership percentage															3.00%
Dr Frost and Mr Pfenniger \| Museum of Science, Inc
Related Party Transaction [Line Items]
Future contributions to related party																				$ 1,000,000.0
Real Estate Holdings LLC
Related Party Transaction [Line Items]
Area of real estate property (in square feet) \| ft²																		29,500
Monthly operating lease payment in year one																		$ 89,000
Monthly operating lease payment in year five																		$ 101,000
OPKO Transaction Shares \| Affiliated Entity \| Xenetic Biosciences, Inc.
Related Party Transaction [Line Items]
Shares issued (in shares) \| shares																			164,062
Reimbursement Of Travel Expense \| Dr Frost
Related Party Transaction [Line Items]
Reimbursement paid to related party for travel															$ 328,000	$ 238,000	$ 361,000
Shares Received Upon Closing of Xenetic Transaction \| Director
Related Party Transaction [Line Items]
Shares received upon closing of transaction (in shares) \| shares																			31,240
Federal Trade Commission Filing Fees \| Chief Technical Officer
Related Party Transaction [Line Items]
Filing fee					$ 125,000
Federal Trade Commission Filing Fees \| Chief Executive Officer
Related Party Transaction [Line Items]
Filing fee						$ 280,000
Series A Warrant \| Neovasc
Related Party Transaction [Line Items]
Warrants to purchase common shares (in shares) \| shares										20,547
Proceeds from exercise of warrants														$ 1,200,000
Series B Warrant \| Neovasc
Related Party Transaction [Line Items]
Warrants to purchase common shares (in shares) \| shares										20,547
Exercise of warrant number of securities received (in shares) \| shares								10,690
Series C Warrant \| Neovasc
Related Party Transaction [Line Items]
Warrants to purchase common shares (in shares) \| shares										8,221
Exercise of warrant number of securities received (in shares) \| shares														22,660
Convertible Debt
Related Party Transaction [Line Items]
Interest rate of notes payable						4.50%
Convertible Debt \| Cocrystal
Related Party Transaction [Line Items]
Payments in equity method investment									$ 1,000,000.0
Convertible Debt \| Cocrystal \| Equity securities
Related Party Transaction [Line Items]
Convertible debt shares issued (in shares) \| shares							538,544
Convertible Debt \| 5% Convertible Notes
Related Party Transaction [Line Items]
Interest rate of notes payable									5.00%
Debt face amount									$ 55,000,000.0
Chief Executive Officer
Related Party Transaction [Line Items]
Private placement agreement value of shares			70,000,000
Chief Technical Officer
Related Party Transaction [Line Items]
Private placement agreement value of shares			2,000,000
Line of Credit \| Unsecured Debt
Related Party Transaction [Line Items]
Credit line capacity			$ 60,000,000
Interest rate of notes payable			10.00%
Line of Credit \| Unsecured Debt \| Dr Frost
Related Party Transaction [Line Items]
Repayments of line of credit		$ 28,800,000
IPO
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares	50,000,000
Price per share of common stock (in dollars per share) \| $ / shares	$ 1.50
Net proceeds in transaction	$ 70,000,000
Over-Allotment Option
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares				4,227,749
Price per share of common stock (in dollars per share) \| $ / shares				$ 1.50
Net proceeds in transaction				$ 6,000,000
Members of Senior Management \| IPO
Related Party Transaction [Line Items]
Shares of common stock issued (in shares) \| shares	2,415,000