Equity-Based Compensation - Narrative (Details)	12 Months Ended
Dec. 31, 2019 USD ($) plan $ / shares shares	Dec. 31, 2018 USD ($) $ / shares	Dec. 31, 2017 USD ($) $ / shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of equity-based incentive compensation plans \| plan	6
Expiration period	10 years
Vesting period	5 years
Excess tax benefits	$ 0	$ 0	$ 0
Unrecognized compensation cost	$ 15,400,000
Weighted-average expected period for recognition	1 year 8 months 15 days
Expected dividend yield	0.00%	0.00%	0.00%
Common stock shares reserved for issuance (in shares) \| shares	22,304,368
Intrinsic value of stock options exercised	$ 100,000	$ 500,000	$ 6,400,000
Weighted average grant date fair value of stock options granted (in dollars per share) \| $ / shares	$ 1.15	$ 2.08	$ 4.50
Fair value of stock options vested	$ 18,600,000	$ 25,800,000	$ 34,000,000
Selling, General and Administrative Expenses
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity based compensation expense	9,700,000	14,700,000	21,200,000
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity based compensation expense	2,000,000.0	4,200,000	5,100,000
Cost of Revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity based compensation expense	$ 1,600,000	2,800,000	2,000,000.0
Modigene
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of equity-based incentive compensation plans \| plan	2
Continuing Operations
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity based compensation expense	$ 13,400,000	$ 21,800,000	$ 28,300,000
Minimum \| 2007 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiration period	7 years
Maximum \| 2007 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiration period	10 years
Employee Stock Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period	4 years
Non-employee Director \| Employee Stock Option
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period	1 year

Number of equity based incentive compensation plans.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Aggregate number of common shares reserved for future issuance.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of cash outflow for realized tax benefit related to deductible compensation cost reported on the entity's tax return for equity instruments in excess of the compensation cost for those instruments recognized for financial reporting purposes.

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Estimated period over which an employee is required to provide service in exchange for the equity-based payment award, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Fair value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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