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Strategic Alliances (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended 20 Months Ended 36 Months Ended
Oct. 12, 2017
May 31, 2016
Jan. 31, 2015
Dec. 31, 2010
Dec. 31, 2017
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2017
Dec. 31, 2017
Mar. 31, 2013
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Initial upfront payment $ 6,000,000                    
Milestone revenue recognized         $ 0            
Grant repayment           $ 0 $ 0 $ 25,889,000      
Ownership percentage         4.00% 4.00%     4.00% 4.00%  
Vifor Fresenius Medical Care Pharma Ltd                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone revenue recognized                 $ 0    
Vifor Fresenius Medical Care Pharma Ltd | Development and License Agreement                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Proceeds from license fees received   $ 50,000,000                  
Vifor Fresenius Medical Care Pharma Ltd | Exclusive Option                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payments, maximum   555,000,000                  
Vifor Fresenius Medical Care Pharma Ltd | Regulatory Milestones                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payments, maximum   37,000,000                  
Vifor Fresenius Medical Care Pharma Ltd | Launch and Sales-based Milestones                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payments, maximum   $ 195,000,000                  
TESARO                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payments, maximum       $ 85,000,000.0              
Milestone payment ranges       30,000,000              
Upfront payment under license agreements       $ 6,000,000              
Maximum period to receive royalties       12 years              
TESARO | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone revenue recognized           $ 10,000,000 $ 0 $ 15,000,000      
Pfizer | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone revenue recognized                   $ 0  
Milestone payments, maximum     $ 275,000,000                
Non-refundable upfront payment     295,000,000     295,000,000          
Additional milestone payment to be received     275,000,000                
Deferred revenue         $ 143,100,000 143,100,000     143,100,000 143,100,000  
RXi Pharmaceuticals Corporation                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payments                     $ 50,000,000
Accrued Expenses | Pfizer | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Deferred revenue         54,300,000 54,300,000     54,300,000 54,300,000  
Other Long-term Liabilities | Pfizer | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Deferred revenue         $ 88,800,000 $ 88,800,000     $ 88,800,000 $ 88,800,000  
Minimum | Pfizer | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payment ranges     20,000,000                
Maximum | Pfizer | Collaborative Arrangement, Product                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Milestone payment ranges     $ 90,000,000                
Pharmsynthez                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Ownership percentage         9.00% 9.00%     9.00% 9.00%  
Phase Two Initiation                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Additional milestone payments 6,000,000                    
Regulatory And Development                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Additional milestone payments 31,000,000                    
Sales Revenue                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Additional milestone payments $ 75,000,000