Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 43,718	$ 91,499
Accounts receivable, net	157,374	165,516
Inventory, net	43,379	49,333
Other current assets and prepaid expenses	45,346	42,513
Total current assets	289,817	348,861
Property, plant and equipment, net	147,386	146,557
Intangible assets, net	631,434	683,835
In-process research and development	646,339	647,347
Goodwill	713,629	717,099
Investments	42,737	40,642
Other assets	9,652	5,615
Total assets	2,480,994	2,589,956
Current liabilities:
Accounts payable	65,613	74,307
Accrued expenses	214,907	230,301
Current portion of 2033 Senior Notes	30,957	0
Current portion of lines of credit and notes payable	6,353	11,926
Total current liabilities	317,830	316,534
2023 Convertible Notes and 2033 Senior Notes	56,597	29,160
Deferred tax liabilities, net	134,112	148,729
Other long-term liabilities, principally contract liabilities, contingent consideration and line of credit	183,812	239,955
Total long-term liabilities	374,521	417,844
Total liabilities	692,351	734,378
Equity:
Common Stock - $0.01 par value, 750,000,000 shares authorized; 560,377,422 and 560,023,745 shares issued at September 30, 2018 and December 31, 2017, respectively	5,604	5,600
Treasury Stock - 549,907 and 549,907 shares at September 30, 2018 and December 31, 2017, respectively	(1,791)	(1,791)
Additional paid-in capital	2,907,017	2,889,256
Accumulated other comprehensive loss	(13,138)	(528)
Accumulated deficit	(1,109,049)	(1,036,959)
Total shareholders’ equity	1,788,643	1,855,578
Total liabilities and equity	$ 2,480,994	$ 2,589,956