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Strategic Alliances (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended 23 Months Ended 39 Months Ended 79 Months Ended
Oct. 12, 2017
May 31, 2016
Jan. 31, 2015
Dec. 31, 2010
Mar. 31, 2018
Mar. 31, 2017
Mar. 31, 2018
Dec. 31, 2017
Mar. 31, 2018
Mar. 31, 2018
Jun. 30, 2017
Mar. 31, 2013
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Upfront payment from development and license agreement $ 6,000,000                      
Milestone revenue recognized             $ 0          
Revenue from transfer of intellectual property and other         $ 15,748,000 $ 15,606,000   $ 15,606,000        
Contract liability         125,000,000   125,000,000 140,400,000 $ 125,000,000 $ 125,000,000    
Contract liabilities         63,642,000   63,642,000 78,990,000 63,642,000 63,642,000    
Contract liabilities         61,378,000   61,378,000 $ 61,388,000 61,378,000 61,378,000    
VFMCRP                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone revenue recognized                 0      
VFMCRP | Development and License Agreement                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
License revenue, initial payment   $ 50,000,000                    
VFMCRP | Regulatory Milestones                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Additional milestone payment to be received   37,000,000                    
VFMCRP | Launch and Sales-based Milestones                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Additional milestone payment to be received   195,000,000                    
VFMCRP | Exclusive Option                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Additional milestone payment to be received   $ 555,000,000                    
Pfizer | Collaborative Arrangement, Product                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone revenue recognized                   0    
Additional milestone payment to be received     $ 275,000,000.0                  
Non-refundable and non-creditable upfront payment     295,000,000                  
Revenue from transfer of intellectual property and other         14,700,000 14,100,000            
Contract liability         116,400,000   116,400,000   116,400,000 116,400,000    
Tesaro                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone revenue recognized         0 $ 0            
Upfront payment under license agreements       $ 6,000,000.0                
Milestone payment received                     $ 30,000,000  
Additional milestone payment       $ 85,000,000                
Period from first commercial sale       12 years                
Written termination threshold       3 months                
Accrued Expenses | Pfizer | Collaborative Arrangement, Product                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contract liabilities         58,800,000   58,800,000   58,800,000 58,800,000    
Other Noncurrent Liabilities | Pfizer | Collaborative Arrangement, Product                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Contract liabilities         $ 57,600,000   $ 57,600,000   $ 57,600,000 $ 57,600,000    
Minimum | Pfizer | Collaborative Arrangement, Product                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Each milestone payment     20,000,000.0                  
Maximum | Pfizer | Collaborative Arrangement, Product                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Each milestone payment     $ 90,000,000.0                  
Pharmsynthez                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Ownership percentage, equity method         9.00%   9.00%   9.00% 9.00%    
Rxi Pharmaceuticals Corporation                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Maximum milestone payments to be received                       $ 50,000,000.0
Phase Two Initiation                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone payment from development and license agreement 6,000,000                      
Regulatory And Development                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone payment from development and license agreement 31,000,000                      
Sales Revenue                        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                        
Milestone payment from development and license agreement $ 75,000,000