Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net income (loss)	$ (48,523)	$ 3,554
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization	51,281	46,780
Non-cash interest	1,294	1,408
Amortization of deferred financing costs	112	74
Losses from investments in investees	7,758	4,333
Equity-based compensation – employees and non-employees	15,844	26,105
Realized loss (gain) on equity securities and disposal of fixed assets	(2,473)	(2,494)
Change in fair value of derivative instruments	(9,519)	188
Change in fair value of contingent consideration	6,738	12,511
Deferred income tax benefit	(23,039)	(8,999)
Changes in assets and liabilities, net of the effects of acquisitions:
Accounts receivable, net	(30,865)	(18,388)
Inventory, net	(443)	(1,763)
Other current assets and prepaid expenses	3,692	(14,309)
Other assets	(254)	732
Accounts payable	9,439	(13,205)
Foreign currency measurement	230	(405)
Deferred revenue	(34,018)	(35,938)
Accrued expenses and other liabilities	(3,837)	33,452
Net cash provided by (used in) operating activities	(56,583)	33,636
Cash flows from investing activities:
Investments in investees	(3,000)	(5,921)
Purchase of marketable securities	(5)	(15,630)
Proceeds from the sale of property, plant and equipment	3,398	708
Capital expenditures	(16,805)	(12,866)
Net cash used in investing activities	(16,412)	(33,709)
Cash flows from financing activities:
Proceeds from the exercise of Common Stock options and warrants	1,916	1,912
Borrowings on lines of credit	45,524	9,496
Repayments of lines of credit	(13,525)	(49,341)
Net cash provided by (used in) financing activities	33,915	(37,933)
Effect of exchange rate changes on cash and cash equivalents	877	423
Net decrease in cash and cash equivalents	(38,203)	(37,583)
Cash and cash equivalents at beginning of period	168,733	193,598
Cash and cash equivalents at end of period	130,530	156,015
SUPPLEMENTAL INFORMATION:
Interest paid	748	900
Income taxes paid, net	4,321	7,172
Shares issued upon the conversion of:
Common Stock options and warrants, surrendered in net exercise	1,546	325
OPKO Health Europe
Issuance of capital stock for contingent consideration settlement:
Capital stock issued	$ 303	$ 313