Acquisitions, Investments and Licenses - Available for Sale Investments, Sale of Investments and Warrants and Options Narrative (Details) shares in Millions, $ in Millions	6 Months Ended
Jun. 30, 2017 USD ($) shares
Rxi Pharmaceuticals Corporation
Investment [Line Items]
Ownership percentage	2.00%
BioCardia, Inc.
Investment [Line Items]
Ownership percentage	5.00%
Number of shares into which warrants may be converted (in shares)	5.0
ChromaDex
Investment [Line Items]
Ownership percentage	2.00%
MabVax
Investment [Line Items]
Ownership percentage	4.00%
Number of shares into which warrants may be converted (in shares)	0.2
ARNO
Investment [Line Items]
Ownership percentage	0.00%
Xenetic Biosciences, Inc.
Investment [Line Items]
Ownership percentage	4.00%
Number of shares into which warrants may be converted (in shares)	0.5
Other than Temporary Impairment Losses, Investments, Available-for-sale Securities \| $	$ 0.6
Neovasc
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	1.0
Cocrystal
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	1.0
Sevion
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	0.3
InCellDx, Inc
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	0.7
Rxi
Investment [Line Items]
Number of shares into which warrants may be converted (in shares)	0.2

Line items represent reporting concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Article 12
-Section 12
-Sentence Column A

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Available-for-Sale Securities, Ownership Percentage

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- Definition

Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(2))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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The amount by which the fair value of an investment in debt and equity securities categorized as Available-for-sale is less than the amortized cost basis or carrying amount of that investment at the balance sheet date and the decline in fair value is deemed to be other than temporary, before considering whether or not such amount is recognized in earnings or other comprehensive income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 45
-Paragraph 8A
-URI http://asc.fasb.org/extlink&oid=82896770&loc=SL6284422-111562

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