Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 130,530	$ 168,733
Accounts receivable, net	251,747	220,284
Inventory, net	48,293	47,228
Other current assets and prepaid expenses	41,946	47,356
Total current assets	472,516	483,601
Property, plant and equipment, net	133,355	122,831
Intangible assets, net	731,134	763,976
In-process research and development	645,957	644,713
Goodwill	712,075	704,603
Investments	34,495	41,139
Other assets	39,162	5,756
Total assets	2,768,694	2,766,619
Current liabilities:
Accounts payable	62,153	53,360
Accrued expenses	206,403	197,955
Current portion of lines of credit and notes payable	14,496	11,981
Total current liabilities	283,052	263,296
2033 Senior Notes and estimated fair value of embedded derivatives, net of discount	34,758	43,701
Deferred tax liabilities, net	142,212	165,331
Other long-term liabilities, principally deferred revenue, contingent consideration and line of credit	201,843	202,483
Total long-term liabilities	378,813	411,515
Total liabilities	661,865	674,811
Equity:
Common Stock - $0.01 par value, 750,000,000 shares authorized; 559,955,118 and 558,576,051 shares issued at June 30, 2017 and December 31, 2016, respectively	5,600	5,586
Treasury Stock - 549,907 and 586,760 shares at June 30, 2017 and December 31, 2016, respectively	(1,791)	(1,911)
Additional paid-in capital	2,863,025	2,845,096
Accumulated other comprehensive loss	(14,070)	(27,009)
Accumulated deficit	(745,935)	(729,954)
Total shareholders’ equity	2,106,829	2,091,808
Total liabilities and equity	$ 2,768,694	$ 2,766,619