Stock Exchange Agreement, Calculated Average Stock Price, Consecutive Trading Days

No definition available.

Name:	opk_StockExchangeAgreementCalculatedAverageStockPriceConsecutiveTradingDays
Namespace Prefix:	opk_
Data Type:	xbrli:durationItemType
Balance Type:	na
Period Type:	duration

- Definition

Stock Exchange Agreement, Stock Received

+ References

No definition available.

+ Details

Name:	opk_StockExchangeAgreementStockReceived
Namespace Prefix:	opk_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Stock Exchange Agreement, Stock Received, Shares

+ References

No definition available.

+ Details

Name:	opk_StockExchangeAgreementStockReceivedShares
Namespace Prefix:	opk_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	duration

- Definition

Stock Exchange Agreement, Stock Transferred

+ References

No definition available.

+ Details

Name:	opk_StockExchangeAgreementStockTransferred
Namespace Prefix:	opk_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

Stock Exchange Agreement, Stock Transferred, Shares

+ References

No definition available.

+ Details

Name:	opk_StockExchangeAgreementStockTransferredShares
Namespace Prefix:	opk_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	duration

- Definition

Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(29))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

+ Details

Name:	us-gaap_CommonStockSharesIssued
Namespace Prefix:	us-gaap_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	instant

- Definition

Contractual interest rate for funds borrowed, under the debt agreement.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22(a)(1))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

+ Details

Name:	us-gaap_DebtInstrumentInterestRateStatedPercentage
Namespace Prefix:	us-gaap_
Data Type:	num:percentItemType
Balance Type:	na
Period Type:	instant

- Definition

For an unclassified balance sheet, amounts due from parties associated with the reporting entity as evidenced by a written promise to pay.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(k)(1))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-03.3)
-URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 850
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (d)
-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39549-107864

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Related Parties
-URI http://asc.fasb.org/extlink&oid=16382449

+ Details

Name:	us-gaap_NotesReceivableRelatedParties
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

The cash outflow for a loan, supported by a promissory note, granted to related parties where one party can exercise control or significant influence over another party; including affiliates, owners or officers and their immediate families, pension trusts, and so forth.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Investing Activities
-URI http://asc.fasb.org/extlink&oid=6516133

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 13
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585

+ Details

Name:	us-gaap_OriginationOfNotesReceivableFromRelatedParties
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

+ Details

Name:	us-gaap_RelatedPartyTransactionLineItems
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

- Details

Name:	dei_LegalEntityAxis=opk_XeneticBiosciencesInc.Member
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	dei_LegalEntityAxis=opk_RelativeCoreMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_RelatedPartyTransactionsByRelatedPartyAxis=opk_RelativeCoreMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_CollateralAxis=us-gaap_SecuritiesPledgedAsCollateralMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

Acquisitions, Investments and Licenses - Other Narrative (Details) - USD ($) $ in Millions		1 Months Ended
	Jan. 05, 2016	Mar. 31, 2016	Jun. 30, 2016	Dec. 31, 2015
Related Party Transaction [Line Items]
Stock received	$ 5.0
Stock transferred	$ 5.0
Stock transferred, shares	494,462
Stock received, shares	10,204,082
Stock Exchange Agreement, Calculated Average Stock Price, Consecutive Trading Days	10 days
Common stock, shares			548,301,575	546,188,516
Xenetic Biosciences, Inc.
Related Party Transaction [Line Items]
Stock Exchange Agreement, Calculated Average Stock Price, Consecutive Trading Days	10 days
Relative Core
Related Party Transaction [Line Items]
Interest rate on notes payable		10.00%
Relative Core
Related Party Transaction [Line Items]
Payment for promissory note		$ 5.0
Promissory note receivable		$ 5.0
Securities Pledged as Collateral
Related Party Transaction [Line Items]
Common stock, shares		494,462
Securities Pledged as Collateral \| Xenetic Biosciences, Inc.
Related Party Transaction [Line Items]
Common stock, shares		4,000,000