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Composition of Certain Financial Statement Captions - Changes in Goodwill (Details)
$ in Thousands
6 Months Ended
Jun. 30, 2016
USD ($)
Goodwill [Roll Forward]  
Beginning balance $ 743,348
Purchase accounting adjustments (54,300)
Foreign exchange 2,012
Ending balance 691,060
Bio-Reference  
Goodwill [Roll Forward]  
Purchase accounting adjustments (54,300)
Ending balance 386,900
Pharmaceutical | CURNA  
Goodwill [Roll Forward]  
Beginning balance 4,827
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance 4,827
Pharmaceutical | EirGen  
Goodwill [Roll Forward]  
Beginning balance 81,139
Purchase accounting adjustments 0
Foreign exchange 1,573
Ending balance 82,712
Pharmaceutical | FineTech  
Goodwill [Roll Forward]  
Beginning balance 11,698
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance 11,698
Pharmaceutical | OPKO Chile  
Goodwill [Roll Forward]  
Beginning balance 4,517
Purchase accounting adjustments 0
Foreign exchange 309
Ending balance 4,826
Pharmaceutical | OPKO Biologics  
Goodwill [Roll Forward]  
Beginning balance 139,784
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance 139,784
Pharmaceutical | OPKO Health Europe  
Goodwill [Roll Forward]  
Beginning balance 7,191
Purchase accounting adjustments 0
Foreign exchange 130
Ending balance 7,321
Pharmaceutical | OPKO Renal  
Goodwill [Roll Forward]  
Beginning balance 2,069
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance 2,069
Diagnostics | Bio-Reference  
Goodwill [Roll Forward]  
Beginning balance 441,158
Purchase accounting adjustments (54,300)
Foreign exchange 0
Ending balance 386,858
Diagnostics | OPKO Diagnostics  
Goodwill [Roll Forward]  
Beginning balance 17,977
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance 17,977
Diagnostics | OPKO Lab  
Goodwill [Roll Forward]  
Beginning balance 32,988
Purchase accounting adjustments 0
Foreign exchange 0
Ending balance $ 32,988