Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 156,015	$ 193,598
Marketable securities	15,634	0
Accounts receivable, net	213,372	193,875
Inventory, net	42,046	39,681
Other current assets and prepaid expenses	78,506	26,904
Total current assets	505,573	454,058
Property, plant and equipment, net	128,274	131,798
Intangible assets, net	804,445	638,152
In-process research and development	606,035	792,275
Goodwill	691,060	743,348
Investments, net	34,249	34,716
Other assets	4,385	4,841
Total assets	2,774,021	2,799,188
Current liabilities:
Accounts payable	61,062	72,535
Accrued expenses	209,848	167,899
Current portion of lines of credit and notes payable	10,327	11,468
Total current liabilities	281,237	251,902
2033 Senior Notes and estimated fair value of embedded derivatives, net of discount	45,233	48,986
Deferred tax liabilities, net	207,595
Deferred tax liabilities, net		226,036
Other long-term liabilities, principally deferred revenue and line of credit	224,316	292,470
Total long-term liabilities	477,144	567,492
Total liabilities	758,381	819,394
Equity:
Common Stock - $0.01 par value, 750,000,000 shares authorized; 548,301,575 and 546,188,516 shares issued at June 30, 2016 and December 31, 2015, respectively	5,483	5,462
Treasury Stock - 586,760 and 1,120,367 shares at June 30, 2016 and December 31, 2015, respectively	(1,911)	(3,645)
Additional paid-in capital	2,736,816	2,705,385
Accumulated other comprehensive loss	(23,431)	(22,537)
Accumulated deficit	(701,317)	(704,871)
Total shareholders’ equity	2,015,640	1,979,794
Total liabilities and equity	$ 2,774,021	$ 2,799,188