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Segments (Details) (USD $)
In Thousands, unless otherwise specified
 3 Months Ended 12 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Dec. 31, 2014
Customer
Segment Reporting Information [Line Items]      
Product revenues $ 15,486us-gaap_SalesRevenueGoodsNet $ 19,828us-gaap_SalesRevenueGoodsNet  
Revenue from services 2,069us-gaap_SalesRevenueServicesNet 1,970us-gaap_SalesRevenueServicesNet  
Revenue from transfer of intellectual property 12,529opk_RevenueFromTransferOfIntellectualProperty 476opk_RevenueFromTransferOfIntellectualProperty  
Operating (loss) income (56,914)us-gaap_OperatingIncomeLoss (30,277)us-gaap_OperatingIncomeLoss  
Depreciation and amortization 3,525us-gaap_DepreciationDepletionAndAmortization 3,564us-gaap_DepreciationDepletionAndAmortization  
Gain (Loss) on Investments (1,761)us-gaap_GainLossOnInvestments (2,056)us-gaap_GainLossOnInvestments  
Total revenues 30,084us-gaap_SalesRevenueNet 22,274us-gaap_SalesRevenueNet  
Assets 1,512,249us-gaap_Assets [1]   1,267,664us-gaap_Assets [1]
Goodwill 223,219us-gaap_Goodwill [1]   224,292us-gaap_Goodwill [1]
United States [Member]      
Segment Reporting Information [Line Items]      
Total revenues 2,493us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_US		 2,446us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_US		  
IRELAND [Member]      
Segment Reporting Information [Line Items]      
Total revenues 12,104us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IE		 0us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IE		  
Chile [Member]      
Segment Reporting Information [Line Items]      
Total revenues 6,452us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_CL		 7,285us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_CL		  
Spain [Member]      
Segment Reporting Information [Line Items]      
Total revenues 3,937us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_ES		 6,150us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_ES		  
Israel [Member]      
Segment Reporting Information [Line Items]      
Total revenues 4,213us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IL		 4,546us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_IL		  
Mexico [Member]      
Segment Reporting Information [Line Items]      
Total revenues 885us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_MX		 1,831us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_MX		  
Other [Member]      
Segment Reporting Information [Line Items]      
Total revenues 0us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_UY		 16us-gaap_SalesRevenueNet
/ us-gaap_StatementGeographicalAxis
= country_UY		  
Corporate, Non-Segment [Member]      
Segment Reporting Information [Line Items]      
Revenue from services 60us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		 60us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		  
Revenue from transfer of intellectual property 0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		 0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		  
Operating (loss) income (9,979)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		 (6,137)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		  
Depreciation and amortization 22us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		 24us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		  
Gain (Loss) on Investments 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		  
Assets 308,467us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		   95,094us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Goodwill 0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember		   0us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_CorporateNonSegmentMember
Segment Reconciling Items [Member]      
Segment Reporting Information [Line Items]      
Operating (loss) income (534)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_MaterialReconcilingItemsMember		 (489)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_MaterialReconcilingItemsMember		  
Pharmaceutical | Operating Segments [Member]      
Segment Reporting Information [Line Items]      
Product revenues 15,486us-gaap_SalesRevenueGoodsNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 19,828us-gaap_SalesRevenueGoodsNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Revenue from services 0us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 0us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Revenue from transfer of intellectual property 12,529opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 285opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Operating (loss) income (37,924)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 (16,573)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Depreciation and amortization 1,756us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 1,849us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Gain (Loss) on Investments (1,761)us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		 (2,056)us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		  
Assets 1,098,031us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		   1,064,498us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Goodwill 172,254us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember		   173,327us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_PharmaceuticalMember
Diagnostics | Operating Segments [Member]      
Segment Reporting Information [Line Items]      
Revenue from services 2,009us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		 1,910us-gaap_SalesRevenueServicesNet
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		  
Revenue from transfer of intellectual property 0opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		 191opk_RevenueFromTransferOfIntellectualProperty
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		  
Operating (loss) income (8,477)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		 (7,078)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		  
Depreciation and amortization 1,747us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		 1,691us-gaap_DepreciationDepletionAndAmortization
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		  
Gain (Loss) on Investments 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		 0us-gaap_GainLossOnInvestments
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		  
Assets 105,751us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		   108,072us-gaap_Assets
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Goodwill $ 50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember		   50,965us-gaap_Goodwill
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= opk_DiagnosticsMember
Accounts Receivable | Customer Concentration Risk      
Segment Reporting Information [Line Items]      
Concentration Risk, Number of Customers 0opk_ConcentrationRiskNumberofCustomers
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= us-gaap_CustomerConcentrationRiskMember		   0opk_ConcentrationRiskNumberofCustomers
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= us-gaap_CustomerConcentrationRiskMember
Concentration Risk, Percentage 10.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= us-gaap_CustomerConcentrationRiskMember		   10.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= us-gaap_CustomerConcentrationRiskMember
[1] As of March 31, 2015 and December 31, 2014, total assets include $7.1 million and $7.6 million, respectively, and total liabilities include $12.1 million and $12.1 million, respectively, related to SciVac Ltd (“SciVac”), previously known as SciGen (I.L.) Ltd, a consolidated variable interest entity. SciVac’s consolidated assets are owned by SciVac and SciVac’s consolidated liabilities have no recourse against us. Refer to Note 5.