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Acquisitions, Investments, and Licenses - Summary of Investments (Details) (USD $)
In Thousands, unless otherwise specified
Mar. 31, 2015
Dec. 31, 2014
Business Combinations [Abstract]    
Equity method investments, investment carrying value $ 7,219opk_EquityMethodInvestmentExcludingVariableInterestEntity  
Equity method investment, underlying equity in net assets 19,050us-gaap_EquityMethodInvestmentUnderlyingEquityInNetAssets  
Variable interest entity, equity method 939opk_EquityMethodInvestmentVariableInterestEntity  
Available for sale investments 4,499us-gaap_AvailableForSaleSecuritiesNoncurrent  
Warrants and options 9,723opk_StockOptionandWarrantInvestments  
Total carrying value of investments $ 22,380us-gaap_LongTermInvestments [1] $ 22,453us-gaap_LongTermInvestments [1]
[1] As of March 31, 2015 and December 31, 2014, total assets include $7.1 million and $7.6 million, respectively, and total liabilities include $12.1 million and $12.1 million, respectively, related to SciVac Ltd (“SciVac”), previously known as SciGen (I.L.) Ltd, a consolidated variable interest entity. SciVac’s consolidated assets are owned by SciVac and SciVac’s consolidated liabilities have no recourse against us. Refer to Note 5.