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Acquisitions, Investments, and Licenses - Textual (Details)
3 Months Ended 1 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 1 Months Ended 0 Months Ended 3 Months Ended
Mar. 31, 2015
USD ($)
Mar. 31, 2014
USD ($)
Dec. 31, 2014
USD ($)
Jun. 30, 2012
SciVac
Variable Interest Entity, Primary Beneficiary
member
Mar. 31, 2015
SciVac
Variable Interest Entity, Primary Beneficiary
USD ($)
Mar. 31, 2015
Sevion
Dec. 31, 2014
Sevion
Mar. 31, 2015
Cocrystal
Dec. 31, 2014
Cocrystal
Mar. 31, 2015
ARNO
Dec. 31, 2014
ARNO
Mar. 31, 2015
Neovasc
Dec. 31, 2014
Neovasc
Jan. 31, 2014
Pharmsynthez
Apr. 30, 2013
Pharmsynthez
USD ($)
Apr. 30, 2013
Pharmsynthez
RUB
Mar. 31, 2015
Pharmsynthez
USD ($)
Mar. 31, 2014
Pharmsynthez
USD ($)
Mar. 31, 2015
Zebra
Oct. 31, 2013
Zebra
Series A Preferred Stock
Oct. 31, 2013
Zebra
Restricted Stock
Apr. 17, 2014
Inspiro
USD ($)
Apr. 17, 2014
Inspiro
USD ($)
Mar. 31, 2015
ChromaDex [Member]
Mar. 31, 2015
Rxi Pharmaceuticals Corporation [Member]
Mar. 31, 2015
Cocrystal
Mar. 31, 2015
Pharmsynthez
Mar. 31, 2015
Sevion
Mar. 31, 2015
Non-Invasive Monitoring Systems, Inc. [Member]
Mar. 31, 2015
Neovasc
Mar. 31, 2015
ARNO
Mar. 31, 2014
Other Income [Member]
USD ($)
Jun. 30, 2015
Scenario, Forecast [Member]
Jun. 30, 2015
Scenario, Forecast [Member]
SciVac
Business Acquisition [Line Items]                                                                    
Inspiro stock purchase agreement                                             100.00%us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                     
Cash paid at closing date                                           $ 1,500,000us-gaap_PaymentsToAcquireBusinessesGross
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                       
Delivery of common stock                                           999,556us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                       
Common stock value                                             8,600,000us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                     
Stock price                                             $ 8.57us-gaap_SharePrice
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                     
Number of trading days                                           10 days                        
Average share price                                           $ 9.00opk_BusinessAcquisitionEquityInterestIssuedOrIssuableVolumeWeightedAveragePricePerShare
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                       
In-process research and development                                           10,100,000us-gaap_ResearchAndDevelopmentInProcess
/ us-gaap_BusinessAcquisitionAxis
= opk_InspiroMedicalLtd.Member
                       
Warrants to purchase common shares             100,000us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_SevionMember
  1,000,000us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_CocrystalMember
  800,000us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_ARNOMember
  1,000,000us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_NeovascMember
                                         
Number of shares purchased                             13,600,000opk_EquityMethodInvestmentNumberOfSharesPurchased
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
13,600,000opk_EquityMethodInvestmentNumberOfSharesPurchased
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                   
Asset Purchase Agreement                             9,600,000opk_EquityMethodInvestmentAmountOfSharesPurchased
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                     
Number of share options received in purchase agreement                             12,000,000opk_EquityMethodInvestmentNoteReceivableShareOption
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
12,000,000opk_EquityMethodInvestmentNoteReceivableShareOption
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                   
Proceeds to be received from sale of proprietary technology                             8,100,000opk_EquityMethodInvestmentNoteReceivableCashOption
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
265,000,000opk_EquityMethodInvestmentNoteReceivableCashOption
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                   
Shares Received In Satisfaction of Notes Receivable                           12,000,000opk_SharesReceivedInSatisfactionofNotesReceivable
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                       
Deferred revenue 288,800,000us-gaap_DeferredRevenue   6,700,000us-gaap_DeferredRevenue                       9,500,000us-gaap_DeferredRevenue
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                                     
Period for development of technology                             3 years 3 years                                    
Revenue related to our license agreements                                 0us-gaap_LicenseAndServicesRevenue
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
500,000us-gaap_LicenseAndServicesRevenue
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                               
Revenue collaboration agreement, offset to research and development                                 200,000opk_RevenueReceivedFromCollaborationAgreementOffsettoResearchandDevelopment
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
400,000opk_RevenueReceivedFromCollaborationAgreementOffsettoResearchandDevelopment
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_PharmsynthezMember
                               
Investment Owned, Balance, Shares                                       840,000us-gaap_InvestmentOwnedBalanceShares
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_ZebraMember
/ us-gaap_StatementClassOfStockAxis
= us-gaap_SeriesAPreferredStockMember
                           
Stock ownership percentage       50.00%us-gaap_VariableInterestEntityOwnershipPercentage
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
45.00%us-gaap_VariableInterestEntityOwnershipPercentage
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
                                                        30.00%us-gaap_VariableInterestEntityOwnershipPercentage
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_StatementScenarioAxis
= us-gaap_ScenarioForecastMember
Additional working capital         6,600,000us-gaap_DueFromAffiliates
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
                                                         
Number of members of board of directors       5opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectors
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
                                                           
Number of members of board of directors appointed by reporting entity       3opk_VariableInterestEntityQualitativeorQuantitativeInformationNumberofMembersofBoardofDirectorsAppointedbyReportingEntity
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
                                                           
Percent of board of directors appointed by reporting entity       60.00%opk_VariableInterestEntityQualitativeorQuantitativeInformationPercentofBoardofDirectorsAppointedByReportingEntity
/ dei_LegalEntityAxis
= opk_SciVacMember
/ us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis
= us-gaap_VariableInterestEntityPrimaryBeneficiaryMember
                                                           
Shares Received As Gift                                         900,000opk_SharesReceivedAsGift
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_ZebraMember
/ us-gaap_StatementClassOfStockAxis
= us-gaap_RestrictedStockMember
                         
Ownership percentage           4.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_SevionMember
  8.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_CocrystalMember
  4.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_ARNOMember
  5.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_NeovascMember
            27.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= opk_ZebraMember
            8.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ invest_InvestmentAxis
= opk_CocrystalMember
17.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ invest_InvestmentAxis
= opk_PharmsynthezMember
4.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ invest_InvestmentAxis
= opk_SevionMember
1.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ invest_InvestmentAxis
= opk_NonInvasiveMonitoringSystemsInc.Member
5.00%us-gaap_EquityMethodInvestmentOwnershipPercentage
/ invest_InvestmentAxis
= opk_NeovascMember
       
Total assets of equity method investees 373,400,000us-gaap_EquityMethodInvestmentSummarizedFinancialInformationAssets                                                                  
Total liabilities of equity method investees (51,000,000)us-gaap_EquityMethodInvestmentSummarizedFinancialInformationLiabilities                                                                  
Net losses of equity method investees (37,800,000)us-gaap_EquityMethodInvestmentSummarizedFinancialInformationNetIncomeLoss                                                                  
Equity Method Investment, Quoted Market Value 112,100,000us-gaap_EquityMethodInvestmentQuotedMarketValue                                                                  
Available-for-Sale Securities, Ownership Percentage                                               2.00%opk_AvailableforSaleSecuritiesOwnershipPercentage
/ invest_InvestmentAxis
= opk_ChromaDexMember
10.00%opk_AvailableforSaleSecuritiesOwnershipPercentage
/ invest_InvestmentAxis
= opk_RxiPharmaceuticalsCorporationMember
          4.00%opk_AvailableforSaleSecuritiesOwnershipPercentage
/ invest_InvestmentAxis
= opk_ARNOMember
     
Gain (Loss) on Sale of Investments $ 216,000us-gaap_GainLossOnSaleOfInvestments $ 1,273,000us-gaap_GainLossOnSaleOfInvestments                                                           $ 1,300,000us-gaap_GainLossOnSaleOfInvestments
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_OtherIncomeMember
   
Ownership percentage by shareholder                                                                 68.40%opk_OwnershipPercentagebyShareholder
/ us-gaap_StatementScenarioAxis
= us-gaap_ScenarioForecastMember