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Loss Per Share (Details)
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Number of common stock warrant and common stock options exercised 21,735,636opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercised  
Number of common stock issued for stock warrant and stock options exercised 20,529,027opk_StockIssuedDuringPeriodSharesStockOptionsandWarrantsExercisedNetofSharesSurrenderedinLieuofCashPayment  
Shares surrendered in lieu of cash payment 1,206,609opk_SharesSurrenderedInLieuOfCashPayment  
Common stock investments, available for sale    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Potential common shares 17,489,421us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_CommonStockMember
29,874,112us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_CommonStockMember