Composition of Certain Financial Statement Captions (Details) (USD $) In Thousands, unless otherwise specified	Mar. 31, 2014		Dec. 31, 2013
Accounts receivable, net
Accounts receivable	$ 21,230		$ 21,652
Less: allowance for doubtful accounts	(1,566)		(1,885)
Accounts receivable, net	19,664	[1]	19,767	[1]
Inventories, net
Finished products	12,880		13,374
Work in-process	1,112		1,350
Raw materials	5,355		4,132
Less: inventory reserve	(482)		(777)
Inventory, net	18,865	[1]	18,079	[1]
Prepaid expense and other assets:
Prepaid supplies	1,919		945
Prepaid insurance	902		892
Pharmsynthez notes receivable	0		6,151
Other receivables	605		1,985
Taxes recoverable	1,266		3,458
Other	5,655		5,653
Prepaid expenses and other current assets	10,347	[1]	19,084	[1]
Intangible assets, net:
Less: accumulated amortization	(26,819)		(24,403)
Intangible assets, net	71,921	[1]	74,533	[1]
Accrued expenses:
Taxes payable	124		702
Deferred revenue	8,112		7,639
Clinical trials	4,710		3,342
Professional fees	1,108		402
Employee benefits	5,451		4,399
Deferred acquisition payments, net of discount	840		5,465
Contingent consideration	25,722		28,047
Other	12,705		15,878
Accrued expenses	58,772	[1]	65,874	[1]
Other long-term liabilities:
Mortgages and other debts payable	3,101		3,270
Deferred tax liabilities	166,068		166,435
Other, including deferred revenue	679		1,509
Other long-term liabilities	215,142	[1]	214,775	[1]
Cytochroma [Member]
Other long-term liabilities:
Contingent consideration	36,127		34,401
Farmadiet [Member]
Other long-term liabilities:
Contingent consideration	248		504
OPKO Diagnostics [Member]
Other long-term liabilities:
Contingent consideration	8,593		8,340
CURNA [Member]
Other long-term liabilities:
Contingent consideration	326		316
Technologies [Member]
Intangible assets, net:
Intangible assets	53,020		51,660
Customer relationships [Member]
Intangible assets, net:
Intangible assets	22,525		22,725
Product registrations [Member]
Intangible assets, net:
Intangible assets	9,731		9,692
Tradenames [Member]
Intangible assets, net:
Intangible assets	3,621		3,669
Covenants not to compete [Member]
Intangible assets, net:
Intangible assets	8,670		8,671
Other [Member]
Intangible assets, net:
Intangible assets	$ 1,173		$ 2,519

[1] As of March 31, 2014 and December 31, 2013, total assets include $6.8 million and $6.7 million, respectively, and total liabilities include $11.4 million and $10.4 million, respectively, related to SciVac Ltd (“SciVac”), previously known as SciGen (I.L.) Ltd, a consolidated variable interest entity. SciVac’s consolidated assets are owned by SciVac and SciVac’s consolidated liabilities have no recourse against us. Refer to Note 5.