<SEC-DOCUMENT>0000898860-22-000003-index.html : 20220819
<SEC-HEADER>0000898860-22-000003.hdr.sgml : 20220819
<ACCEPTANCE-DATETIME>20220819160527
ACCESSION NUMBER:		0000898860-22-000003
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220819
DATE AS OF CHANGE:		20220819
GROUP MEMBERS:		FROST GAMMA INVESTMENTS TRUST
GROUP MEMBERS:		FROST NEVADA INVESTMENTS TRUST
GROUP MEMBERS:		PHILLIP FROST, M.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OPKO HEALTH, INC.
		CENTRAL INDEX KEY:			0000944809
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				752402409
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-51671
		FILM NUMBER:		221180790

	BUSINESS ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137
		BUSINESS PHONE:		305-575-4181

	MAIL ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD.
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Opko Health, Inc.
		DATE OF NAME CHANGE:	20070621

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	eXegenics Inc
		DATE OF NAME CHANGE:	20040505

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXEGENICS INC
		DATE OF NAME CHANGE:	20011114

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FROST PHILLIP MD ET AL
		CENTRAL INDEX KEY:			0000898860

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	MAIL ADDRESS:	
		STREET 1:		4400 BISCAYNE BLVD
		CITY:			MIAMI
		STATE:			FL
		ZIP:			33137-3227
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>frostsc13-da6x24x22.htm
<DESCRIPTION>SC 13D/A
<TEXT>
Document 1 - file: frostsc13-da6x24x22.htm

</DOCUMENT>
</SEC-DOCUMENT>