X0508 4 2023-10-15 0 0001818331 GeneDx Holdings Corp. WGS 0000943431 RUCH JOSHUA C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER STAMFORD CT 06902 1 0 0 0 0 Class A Common Stock 2023-10-15 4 M 0 129 A 2025 D Class A Common Stock 14844 I By Kariba LLC Class A Common Stock 30137 I By RUGU2 LLC Class A Common Stock 149283 I By VAAL Investment Partners Q9 LP Restricted Stock Unit 2023-10-15 4 M 0 129 0.00 D Class A Common Stock 129 130 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. Mr. Ruch is (i) a managing member of the managing member of the general partner of Vaal Investment Partners Q9 LP ("Q9"), (ii) a managing member of RUGU2 LLC ("RUGU2") and (iii) a managing member of Kariba LLC ("Kariba"). As such, Mr. Ruch exercises voting and investment power with respect to the shares owned by Q9, RUGU2 and Kariba. Mr. Ruch disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. The RSUs will vest in equal annual installments over the three-year period following the grant date of October 15, 2021, subject to the Reporting Person continuing to provide services to the Issuer through each vesting date. /s/ Devin Schaffer, Attorney-in-Fact 2023-10-17